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The Drug-Drug Interactions Ontology
| Preferred Name | dextromethorphan | |
| Synonyms |
(1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-triene C18H25NO |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB00514 |
|
| activates | ||
| AHFScode |
48:16.00 48:08.00
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| ATCCode |
R05DA09
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|
| binds |
http://purl.obolibrary.org/obo/dinto_2714 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2735 http://purl.obolibrary.org/obo/dinto_3364 http://purl.obolibrary.org/obo/dinto_1136 http://purl.obolibrary.org/obo/dinto_2747 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 |
|
| blocks | ||
| CASRN |
125-71-3
|
|
| DBBrand |
hihustan m. trocal novahistine dm creo-terpin methorate hydrobromide triaminic dm long lasting for children benylin pediatric cough suppressant delsym romilar dormethan robitussin pediatric cough suppressant hold dm robitussin maximum strength cough suppressant benylin adult formula cough suppressant cosylan tusilan koffex dm balminil dm benylin dm for children 12 hour diabe-tuss dm syrup novahistex dm metrorat robitussin pediatric calmylin #1 benylin dm for children cough-x balminil dm children medicon pertussin cs children's strength vicks 44 cough relief canfodion pertussin dm extra strength sucrets 4 hour cough suppressant benylin dm 12 hour benylin dm delsym cough formula antussan methorphan tussade dormetan
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|
| DBSynonym |
dextromethorphan bromhydrate levometorfano [inn-spanish] dexyromethorphan levomethorphan [ban:dcf:inn] l-methorphan dextrometorfano [inn-spanish] dextromethorfan [czech] dextrometorphan demorphan dextromorphan d-methorphan hydrobromide destrometerfano [dcit] demorphine demorphan hydrobromide levomethorphane [inn-french] dextromethorphan bromide delta-methorphan d-methorphan levomethorphanum [inn-latin] levomethorphan
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| Definition |
The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem]
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|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_2735 |
|
| InChI |
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1
|
|
| InChIKey |
InChIKey=MKXZASYAUGDDCJ-CGTJXYLNSA-N
|
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2714 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 |
|
| label |
dextromethorphan
|
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_9943 http://purl.obolibrary.org/obo/CHEBI_68642 http://purl.obolibrary.org/obo/CHEBI_7936 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/dinto_DB00780 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/CHEBI_63637 http://purl.obolibrary.org/obo/dinto_DB01247 http://purl.obolibrary.org/obo/dinto_DB00752 http://purl.obolibrary.org/obo/dinto_DB01171 http://purl.obolibrary.org/obo/dinto_DB01105 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/CHEBI_70707 http://purl.obolibrary.org/obo/CHEBI_63620 http://purl.obolibrary.org/obo/dinto_DB01037 http://purl.obolibrary.org/obo/dinto_DB06273 http://purl.obolibrary.org/obo/CHEBI_10124 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB01341 |
|
| modulates |
http://purl.obolibrary.org/obo/dinto_3364 http://purl.obolibrary.org/obo/dinto_2747 |
|
| prefixIRI |
obo2:dinto_DB00514
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|
| prefLabel |
dextromethorphan
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|
| SMILES |
[H][C@@]12CCCC[C@@]11CCN(C)[C@@H]2CC2=C1C=C(OC)C=C2
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|
| Synonym |
(1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-triene C18H25NO
|
|
| xref |
National Drug Code Directory:63824-171-63 Drugs.com:http://www.drugs.com/dextromethorphan.html Wikipedia:http://en.wikipedia.org/wiki/Dextromethorphan ChEBI:4470 PharmGKB:PA449273 Drugs Product Database (DPD):816000
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| subClassOf |
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