The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	promethazine
Synonyms	prometazina (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine Promethazine promethazine promethazinum 10-[2-(dimethylamino)propyl]phenothiazine dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine proazamine N-(2'-dimethylamino-2'-methyl)ethylphenothiazine C17H20N2S N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine 10-(2-Dimethylaminopropyl)phenothiazine
ID	http://purl.obolibrary.org/obo/CHEBI_8461
AHFScode	04:04.12
ATCCode	R06AD05 D04AA10 R06AD02
binds	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0234 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_0703 http://purl.obolibrary.org/obo/dinto_3887 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_2097 http://purl.obolibrary.org/obo/dinto_0465
blocks	http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_0703 http://purl.obolibrary.org/obo/dinto_3887 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_2097
CASRN	60-87-7
DBBrand	pyrethiazine phencen fargan iergigan histargan dimapp aprobit remsed protazine hiberna phenargan promethaine phenergan avomine diprozin fenergan prometazin valergine duplamin pilpophen prometh plain phenergan fortis prometasin zipan-25 provigan genphen mymethazine fortis phensedyl fenazil allergan tanidil procit phargan diprazine lergigan thiergan prometh fortis pipolphen dorme fenetazina fellozine promethacon promethegan vallergine pyrethia romergan lercigan prorex isophenergan diphergan
DBname	promethazine
DBSynonym	lilly 1516 proazaimine promazinamide prothazine isopromethazine promethazin promezathine proazamine promethiazine promethazine hcl prothazin prometazine
Definition	A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0001431 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001050 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000686 http://purl.obolibrary.org/obo/OAE_0000480
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1071
has role	http://purl.obolibrary.org/obo/CHEBI_37955 http://purl.obolibrary.org/obo/CHEBI_36333 http://purl.obolibrary.org/obo/CHEBI_50919 http://purl.obolibrary.org/obo/CHEBI_35717 http://purl.obolibrary.org/obo/CHEBI_59683 http://purl.obolibrary.org/obo/CHEBI_50857
InChI	InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
InChIKey	InChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_1440
is metabolised by	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0465
is substrate of	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0465
label	promethazine
may interact with	http://purl.obolibrary.org/obo/CHEBI_4469 http://purl.obolibrary.org/obo/dinto_DB00579 http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_5000 http://purl.obolibrary.org/obo/CHEBI_9943 http://purl.obolibrary.org/obo/CHEBI_5280 http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB01579 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/dinto_DB01578 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/CHEBI_8874 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_4530 http://purl.obolibrary.org/obo/CHEBI_8067 http://purl.obolibrary.org/obo/CHEBI_53289 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_3181 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/dinto_DB04572 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_8080 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/dinto_DB00397 http://purl.obolibrary.org/obo/CHEBI_27796 http://purl.obolibrary.org/obo/dinto_DB01577 http://purl.obolibrary.org/obo/dinto_DB00752 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/CHEBI_5557 http://purl.obolibrary.org/obo/CHEBI_10124 http://purl.obolibrary.org/obo/CHEBI_439329 http://purl.obolibrary.org/obo/CHEBI_3044 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/CHEBI_2679 http://purl.obolibrary.org/obo/dinto_DB06700
modulates	http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_0703 http://purl.obolibrary.org/obo/dinto_3887 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_2097
prefixIRI	obo2:CHEBI_8461
prefLabel	promethazine
related with	http://purl.obolibrary.org/obo/dinto_0234
SMILES	CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)N(C)C CC(CN1c2ccccc2Sc2ccccc12)N(C)C
Synonym	prometazina (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine Promethazine promethazine promethazinum 10-[2-(dimethylamino)propyl]phenothiazine dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine proazamine N-(2'-dimethylamino-2'-methyl)ethylphenothiazine C17H20N2S N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine 10-(2-Dimethylaminopropyl)phenothiazine
xref	PubChem Substance:46507798 ChemSpider:4758 Reaxys:88554 National Drug Code Directory:0143-9869-22 NIST Chemistry WebBook:60-87-7 KEGG DRUG:D00494 DrugBank:DB01069 Wikipedia:http://en.wikipedia.org/wiki/Promethazine Drugs.com:http://www.drugs.com/promethazine.html PharmGKB:PA451128 Drugs Product Database (DPD):583979 Patent:US2530451 ChEMBL:127368 PubChem Compound:4927 CASRN:60-87-7 Patent:US2607773 Wikipedia:Promethazine KEGG COMPOUND:C07404 Gmelin:337077 Beilstein:88554 ChEBI:8461 RxList:http://www.rxlist.com/cgi/generic3/phenergan.htm
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_8461	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	INBANCIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	MCO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8461	DRON	SAME_URI
http://purl.bioontology.org/ontology/SNOMEDCT/372871004	SNOMEDCT	LOOM
https://go.drugbank.com/drugs/DB01069	MDM	LOOM
http://purl.bioontology.org/ontology/SNMI/C-62820	SNMI	LOOM
http://www.case.edu/EpSO.owl#Promethazine	MEPO	LOOM
http://www.drugbank.ca/drugs/DB01069	FTC	LOOM
http://stirdf.jst.go.jp/id/200907048848800824	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.831.690	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011398	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Promethazine	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10179	OCHV	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Promethazine	APAONTO	LOOM
http://purl.bioontology.org/ontology/RCD/X79JO	RCD	LOOM
http://purl.bioontology.org/ontology/LNC/LP15006-7	LOINC	LOOM
http://purl.obolibrary.org/obo/NCIT_C779	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033405	OCHV	LOOM
http://purl.obolibrary.org/obo/OMIT_0012351	OMIT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C779	NCIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016220	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	MCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8461	DRON	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147995	INBANCIDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147995	CIDO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.741.670	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147995	NDFRT	LOOM
http://purl.bioontology.org/ontology/VANDF/4019910	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/D04AA10	ATC	LOOM
http://www.case.edu/EpilepsyOntology.owl#Promethazine	EPSO	LOOM
http://purl.bioontology.org/ontology/ATC/R06AD02	ATC	LOOM
http://purl.bioontology.org/ontology/RXNORM/8745	RXNORM	LOOM
http://purl.bioontology.org/ontology/MESH/D011398	MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D011398	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.369.670	RH-MESH	LOOM
http://purl.jp/bio/4/id/200906006637143209	IOBC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001492	LOINC	LOOM