The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	prednisolone
Synonyms	1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione prednisolona Delta(1)-dehydrocortisol prednisolonum 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene Delta(1)-hydrocortisone metacortandralone Delta(1)-dehydrohydrocortisone prednisolone C21H28O5 hydroretrocortine 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
ID	http://purl.obolibrary.org/obo/CHEBI_8378
activates	http://purl.obolibrary.org/obo/dinto_2874
AHFScode	52:08.08 68:04.00
ATCCode	H02AB07 D10AA02 D07XA02 C05AA04 A07EA01 S01CB02 H02AB04 D07AC14 H02AB06 D07AA01 R01AD02 D07AA03 S03BA02 S02BA03 S01BA04
binds	http://purl.obolibrary.org/obo/dinto_2146 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_2874 http://purl.obolibrary.org/obo/dinto_1440
CASRN	50-24-8
DBBrand	ak-pred predonine predalone t.b.a. econopred cotogesic erbacort paracotol predcor-tba klismacort prenolone ultracortene-hydrogen precortisyl lentosone hydeltrasol predniliderm ocu-pred predate tba deltacortenol fernisolone hydrodeltalone ulacort hostacortin h deltacortril dicortol articulose-50 predair a deltacortril enteric depo-medrol fernisolone-p codelcortone medrol acetate key-pred inflamase forte cortalone lite pred delta-cortef ultracorten h co-hydeltra hydeltrone orapred predni-dome ocu-pred forte metacortandralone cordrol hydrodeltisone meti-derm scherisolon prednicen paracortol i-pred predcor-50 nor-pred t.b.a. prednis predcor-25 sterolone metreton steran precortancyl m-predrol decaprednil predne-dome predair inflamase mild rolisone meticortelone erbasona ultracortene-h hydeltra-tba deltasolone alphadrol predate-50 decortin h pred forte predniretard delta-stab eazolin d dexa-cortidelt hostacortin h solone delta f ophtho-tate predair forte prednelan supercortisol panafcortelone estilsona hydroretrocortine ak-tate fernisolone p di-adreson f flamasone ultracortene h hydeltra cotolone prelone medrol pred mild precortalon donisolone delcortol pediapred dydeltrone predonin ultra pred deltisilone precortilon derpo pd sterane hydroretrocortin
DBname	prednisolone
DBSynonym	prednisolonum [inn-latin] deltahydrocortisone prednisolone acetate prednisolone tebutate predisolone sodium phosphate methylprednisolone acetate prednisolona [inn-spanish] prdl prednisolone sodium phosphate
Definition	A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group.
has effect	http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000489 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0001481 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0001280 http://purl.obolibrary.org/obo/OAE_0001073 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001468 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0001078 http://purl.obolibrary.org/obo/OAE_0001101 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001070 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001291 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000466 http://purl.obolibrary.org/obo/OAE_0001035
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2874
has role	http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_37962 http://purl.obolibrary.org/obo/CHEBI_35472
InChI	InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChIKey=OIGNJSKKLXVSLS-VWUMJDOOSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2496
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901
is substrate of	http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	prednisolone
may interact with	http://purl.obolibrary.org/obo/dinto_DB01401 http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB01399 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_9939 http://purl.obolibrary.org/obo/dinto_DB00306 http://purl.obolibrary.org/obo/CHEBI_3641 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB01355 http://purl.obolibrary.org/obo/dinto_DB01397 http://purl.obolibrary.org/obo/dinto_DB04573 http://purl.obolibrary.org/obo/dinto_DB01294 http://purl.obolibrary.org/obo/dinto_DB04574 http://purl.obolibrary.org/obo/dinto_DB01122 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/CHEBI_15365 http://purl.obolibrary.org/obo/CHEBI_3752 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/dinto_DB01354 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB00545 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/dinto_DB01357 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB01352 http://purl.obolibrary.org/obo/CHEBI_7514 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/CHEBI_41922 http://purl.obolibrary.org/obo/dinto_DB00783 http://purl.obolibrary.org/obo/CHEBI_17263 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/dinto_DB04575 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/dinto_DB00286 http://purl.obolibrary.org/obo/CHEBI_6933 http://purl.obolibrary.org/obo/dinto_DB00977 http://purl.obolibrary.org/obo/CHEBI_251408 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00072 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB01353 http://purl.obolibrary.org/obo/dinto_DB01341 http://purl.obolibrary.org/obo/CHEBI_9073 http://purl.obolibrary.org/obo/dinto_DB01398
modulates	http://purl.obolibrary.org/obo/dinto_2874
prefixIRI	obo2:CHEBI_8378
prefLabel	prednisolone
SMILES	[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO
Synonym	1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione prednisolona Delta(1)-dehydrocortisol prednisolonum 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene Delta(1)-hydrocortisone metacortandralone Delta(1)-dehydrohydrocortisone prednisolone C21H28O5 hydroretrocortine 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
xref	PubChem Substance:46504847 CASRN:1354103 RxList:http://www.rxlist.com/cgi/generic/prednisolone.htm Guide To Pharmacology:2866 BindingDB:19190 HMDB:HMDB14998 National Drug Code Directory:0121-0687-05 ChemSpider:5552 DrugBank:DB00860 PharmGKB:PA451096 Wikipedia:Prednisolone Drugs.com:http://www.drugs.com/cdi/prednisolone-acetate-drops.html ChEBI:8378 Wikipedia:http://en.wikipedia.org/wiki/Prednisolone IUPHAR:2866 Drugs Product Database (DPD):2245532 KEGG COMPOUND:C07369 ChEMBL:127370 CASRN:50-24-8 KEGG DRUG:D00472 PubChem Compound:5755
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_8378	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	INBANCIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	ECTO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8378	OBA	SAME_URI
http://purl.jp/bio/4/id/200906036005597987	IOBC	LOOM
http://bmi.utah.edu/ontologies/peontology/C0032950	RAO	LOOM
http://purl.bioontology.org/ontology/ATC/A07EA01	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.432.769.795	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/8638	RXNORM	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146334	NDFRT	LOOM
http://purl.bioontology.org/ontology/ATC/S01BA04	ATC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/116601002	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/ATC/H02AB06	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D011239	BERO	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043296	PDQ	LOOM
http://stirdf.jst.go.jp/id/200907039479477055	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/A01AC04	ATC	LOOM
http://purl.bioontology.org/ontology/CSP/0059-8215	CRISP	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU062945	LOINC	LOOM
http://purl.bioontology.org/ontology/LNC/LP18169-0	LOINC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C769	NCIT	LOOM
http://purl.bioontology.org/ontology/ATC/S02BA03	ATC	LOOM
https://go.drugbank.com/drugs/DB00860	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10042	OCHV	LOOM
http://purl.bioontology.org/ontology/ATC/R01AD02	ATC	LOOM
http://webprotege.stanford.edu/RMLTPoYQg83oLCbnC9p0or	COPDO	LOOM
http://purl.bioontology.org/ontology/ATC/D07AA03	ATC	LOOM
http://purl.bioontology.org/ontology/ATC/C05AA04	ATC	LOOM
http://purl.obolibrary.org/obo/NCIT_C769	BERO	LOOM
http://purl.bioontology.org/ontology/VANDF/4017988	VANDF	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018695	PMAPP-PMO	LOOM
http://scai.fraunhofer.de/MSOntology#Prednisolone	MSO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0032950	OCHV	LOOM
http://purl.obolibrary.org/obo/OMIT_0012203	OMIT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146334	ODAE	LOOM
http://www.drugbank.ca/drugs/DB00860	FTC	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	ODNAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_8378	OBA	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Prednisolone	APAONTO	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00183	OCIMIDO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011239	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D011239	MESH	LOOM
http://purl.bioontology.org/ontology/ATC/S03BA02	ATC	LOOM
http://purl.bioontology.org/ontology/ATC/S01CB02	ATC	LOOM
http://www.co-ode.org/ontologies/galen#Prednisolone	GALEN	LOOM
http://purl.bioontology.org/ontology/NDDF/002155	NDDF	LOOM
http://purl.bioontology.org/ontology/ATC/D07XA02	ATC	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00852	COID	LOOM