loading...| Preferred Name |
lurasidone |
|
| Synonyms |
lurasidonum lurasidona (1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.0?,?]decane-3,5-dione C28H36N4O2S lurasidone (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_70735 |
|
| AHFScode |
28:16.08.04 |
|
| ATCCode |
N05AE05 |
|
| blocks |
http://purl.obolibrary.org/obo/dinto_3340 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_1581 |
|
| CASRN |
367514-87-2 |
|
| DBBrand |
latuda |
|
| DBSalt |
lurasidone hydrochloride |
|
| DBSynonym |
sm-13496 |
|
| Definition |
An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizophrenia. Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. (Wikipedia) |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_37887 http://purl.obolibrary.org/obo/CHEBI_48561 |
|
| InChI |
InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1 |
|
| InChIKey |
InChIKey=PQXKDMSYBGKCJA-CVTJIBDQSA-N |
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| is metabolised by | ||
| label |
lurasidone |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/CHEBI_28918 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_17698 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_18243 http://purl.obolibrary.org/obo/CHEBI_3764 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_107736 http://purl.obolibrary.org/obo/CHEBI_7447 http://purl.obolibrary.org/obo/CHEBI_3090 http://purl.obolibrary.org/obo/CHEBI_51450 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01026 |
|
| prefixIRI |
obo2:CHEBI_70735 |
|
| prefLabel |
lurasidone |
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| related with | ||
| SMILES |
O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(CC1)C1=NSC2=CC=CC=C12 [H][C@@]12[C@H]3CC[C@H](C3)[C@]1([H])C(=O)N(C[C@@H]1CCCC[C@H]1CN1CCN(CC1)c1nsc3ccccc13)C2=O |
|
| Synonym |
lurasidonum lurasidona (1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.0?,?]decane-3,5-dione C28H36N4O2S lurasidone (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione |
|
| xref |
CiteXplore:23001538 CASRN:367514-87-2 National Drug Code Directory:63402-312-30 CiteXplore:22217440 CiteXplore:22828971 Patent:EP1652848 Patent:US2012115879 Wikipedia:Lurasidone CiteXplore:22364325 RxList:http://www.rxlist.com/latuda-drug.htm CiteXplore:21474903 Wikipedia:http://en.wikipedia.org/wiki/Lurasidone Patent:US2011263848 CiteXplore:22739469 CiteXplore:21838595 CiteXplore:22570547 CiteXplore:19780705 CiteXplore:22227609 CiteXplore:21349227 CiteXplore:22849428 CiteXplore:22415605 CiteXplore:22900950 ChEMBL:799372 CiteXplore:22395527 CiteXplore:22903391 CiteXplore:22072817 Drugs.com:http://www.drugs.com/cdi/lurasidone.html CiteXplore:22967786 CiteXplore:22559286 CiteXplore:22929996 CiteXplore:22545643 Patent:EP1637530 Patent:US2011263847 Reaxys:11182976 CiteXplore:22868411 ChEBI:70735 CiteXplore:22675261 CiteXplore:22776634 CiteXplore:22332980 |
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| subClassOf |