The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

ezogabine
Synonyms

Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate

N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester

N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester

D-23129

ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate

ethyl N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamate

retigabine

Potiga

C16H18FN3O2

ID

http://purl.obolibrary.org/obo/CHEBI_68584

AHFScode

28:12.92

ATCCode

N03AX21

binds

http://purl.obolibrary.org/obo/dinto_2496

http://purl.obolibrary.org/obo/dinto_3118

http://purl.obolibrary.org/obo/dinto_3115

http://purl.obolibrary.org/obo/dinto_3116

http://purl.obolibrary.org/obo/dinto_4068

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_0265

http://purl.obolibrary.org/obo/dinto_0270

http://purl.obolibrary.org/obo/dinto_0276

http://purl.obolibrary.org/obo/dinto_2047

CASRN

150812-12-7

DBBrand

potiga

DBSynonym

d23129

d-23129

retigabine

ezg

rtg

Definition

Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy. FDA approved in June 10, 2011 under the name of ezogabine.

A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.

has role

http://purl.obolibrary.org/obo/CHEBI_50510

http://purl.obolibrary.org/obo/CHEBI_35623

InChI

InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)

InChIKey

InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2496

is metabolised by

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_0265

http://purl.obolibrary.org/obo/dinto_0270

http://purl.obolibrary.org/obo/dinto_0276

http://purl.obolibrary.org/obo/dinto_2047

is substrate of

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_0265

http://purl.obolibrary.org/obo/dinto_0270

http://purl.obolibrary.org/obo/dinto_0276

http://purl.obolibrary.org/obo/dinto_2047

label

ezogabine

may interact with

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/dinto_DB00904

http://purl.obolibrary.org/obo/CHEBI_6367

http://purl.obolibrary.org/obo/CHEBI_3387

prefixIRI

obo2:CHEBI_68584

prefLabel

ezogabine

related with

http://purl.obolibrary.org/obo/dinto_3118

http://purl.obolibrary.org/obo/dinto_3115

http://purl.obolibrary.org/obo/dinto_3116

http://purl.obolibrary.org/obo/dinto_4068

SMILES

CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N

CCOC(=O)NC1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1

Synonym

Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate

N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester

N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester

D-23129

ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate

ethyl N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamate

retigabine

Potiga

C16H18FN3O2

xref

PubChem Compound:121892

Patent:US2012053238

Reaxys:8072099

KEGG DRUG:D09569

Wikipedia:http://en.wikipedia.org/wiki/Retigabine

CiteXplore:22991134

Patent:US6348486

Drugs.com:http://www.drugs.com/mtm/ezogabine.html

CASRN:150812-12-7

PharmGKB:PA144997862

PubChem Substance:10239851

ChEMBL:161945

Patent:US5384330

Patent:WO2007090409

ChEBI:68584

BindingDB:50143558

Patent:US2002111379

Patent:US2002015730

Patent:WO2011012659

ChemSpider:108740

RxList:http://www.rxlist.com/potiga-drug.htm

KEGG COMPOUND:C13826

National Drug Code Directory:0173-0814-59

Patent:US2002183395

Wikipedia:Ezogabine

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_68584 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_68584 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_68584 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_68584 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_68584 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_68584 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_68584 DRON LOOM
https://go.drugbank.com/drugs/DB04953 MDM LOOM
http://purl.bioontology.org/ontology/VANDF/4030907 VANDF LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026572 PMAPP-PMO LOOM
http://www.case.edu/EpilepsyOntology.owl#Ezogabine EPSO LOOM
http://www.drugbank.ca/drugs/DB04953 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/013807 NDDF LOOM
http://purl.obolibrary.org/obo/NCIT_C72839 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_68584 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_68584 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_68584 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_68584 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_68584 DDSS LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72839 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C101866 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/1112990 RXNORM LOOM
http://purl.bioontology.org/ontology/MESH/C101866 MESH LOOM
http://www.case.edu/EpSO.owl#Ezogabine MEPO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000182972 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU047413 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP173601-8 LOINC LOOM