loading...| Preferred Name |
iloperidone |
|
| Synonyms |
Fanapta Fanapt 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone 1-(4-{3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethanone iloperidonum C24H27FN2O4 iloperidone Zomaril 4'-(3-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone 1-(4-{3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethan-1-one iloperidona |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_65173 |
|
| AHFScode |
28:16.08.04 |
|
| ATCCode |
N05AX14 |
|
| binds |
http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_3340 http://purl.obolibrary.org/obo/dinto_3203 http://purl.obolibrary.org/obo/dinto_4010 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_0656 http://purl.obolibrary.org/obo/dinto_0909 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_1166 http://purl.obolibrary.org/obo/dinto_0234 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 |
|
| blocks |
http://purl.obolibrary.org/obo/dinto_3340 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_3203 http://purl.obolibrary.org/obo/dinto_4010 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_0656 http://purl.obolibrary.org/obo/dinto_0909 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_1166 |
|
| CASRN |
133454-47-4 |
|
| DBBrand |
fiapta fanapt zomaril |
|
| DBSynonym |
hp 873 |
|
| Definition |
Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. made initial inquiries into the drug; however, in May 1996, they discontinued research, and in June 1997 gave research rights to Titan Pharmaceuticals. Titan then handed over worldwide development, manufacturing and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals announced that the Phase III development rights have been acquired by Vanda Pharmaceuticals. FDA approved on May 9, 2009. A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia. |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_48561 |
|
| InChI |
InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3 |
|
| InChIKey |
InChIKey=XMXHEBAFVSFQEX-UHFFFAOYSA-N |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 |
|
| label |
iloperidone |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_7936 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_27958 http://purl.obolibrary.org/obo/dinto_DB01026 |
|
| modulates |
http://purl.obolibrary.org/obo/dinto_3340 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_3203 http://purl.obolibrary.org/obo/dinto_4010 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_0656 http://purl.obolibrary.org/obo/dinto_0909 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_1166 |
|
| prefixIRI |
obo2:CHEBI_65173 |
|
| prefLabel |
iloperidone |
|
| SMILES |
COC1=C(OCCCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C=CC(=C1)C(C)=O COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O |
|
| Synonym |
Fanapta Fanapt 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone 1-(4-{3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethanone iloperidonum C24H27FN2O4 iloperidone Zomaril 4'-(3-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone 1-(4-{3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethan-1-one iloperidona |
|
| xref |
CiteXplore:21600386 ChemSpider:64459 CiteXplore:22453868 CiteXplore:21289324 Drugs.com:http://www.drugs.com/fanapt.html Wikipedia:Iloperidone Wikipedia:http://en.wikipedia.org/wiki/Iloperidone CiteXplore:21474903 BindingDB:50034043 National Drug Code Directory:43068-110-02 CiteXplore:22617084 RxList:http://www.rxlist.com/fanapt-drug.htm CiteXplore:22161738 CiteXplore:22217439 Reaxys:7233425 CASRN:133454-47-4 SUBMITTER:133454-47-4 PubChem Compound:71360 PharmGKB:PA161199368 SUBMITTER:D02666 CiteXplore:22465688 ChEMBL:113949 PubChem Substance:12014542 |
|
| subClassOf |