The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

fenfluramine hydrochloride

Synonyms

C12H17ClF3N

N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-aminium chloride

fenfluramine HCl

N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride

N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine hydrochloride

(+-)-fenfluramine HCl

1-(3-trifluoromethylphenyl)-2-ethylaminopropane hydrochloride

NN-ethyl-alpha-methyl-3-trifluoromethylphenethylamine hydrochloride

(+-)-fenfluramine hydrochloride

ID

http://purl.obolibrary.org/obo/CHEBI_59729

Definition

The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

has role

http://purl.obolibrary.org/obo/CHEBI_50949

http://purl.obolibrary.org/obo/CHEBI_35941

http://purl.obolibrary.org/obo/CHEBI_50507

InChI

InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

InChIKey

InChIKey=ZXKXJHAOUFHNAS-UHFFFAOYSA-N

label

fenfluramine hydrochloride

prefixIRI

obo2:CHEBI_59729

prefLabel

fenfluramine hydrochloride

SMILES

[Cl-].CC[NH2+]C(C)Cc1cccc(c1)C(F)(F)F

Synonym

C12H17ClF3N

N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-aminium chloride

fenfluramine HCl

N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride

N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine hydrochloride

(+-)-fenfluramine HCl

1-(3-trifluoromethylphenyl)-2-ethylaminopropane hydrochloride

NN-ethyl-alpha-methyl-3-trifluoromethylphenethylamine hydrochloride

(+-)-fenfluramine hydrochloride

xref

ChEMBL:1478487

DrugBank:DB00574

Beilstein:5652886

CASRN:404-82-0

KEGG DRUG:D04148

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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