The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	fluphenazine
Synonyms	C22H26F3N3OS 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine Fluorphenazine 2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol 4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol flufenazina 10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine 2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine Fluphenazine Triflumethazine fluphenazine Fluorfenazine 4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol fluphenazinum 10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine Fluorophenazine 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
ID	http://purl.obolibrary.org/obo/CHEBI_5123
AHFScode	28:16.08.24
ATCCode	N05AB02
binds	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909
blocks	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909
CASRN	69-23-8
DBBrand	apo-fluphenazine prolixine prolixin enanthate moditen hcl elinol permitil concentrate siqualon vespazine yespazine prolixin concentrate moditen enanthate siqualine prolixin modecate sevinol
DBname	fluphenazine
DBSynonym	fluorfenazine fluphenazine hcl fluorophenazine triflumethazine fluorphenazine fluphenazine decanoate
Definition	A phenothiazine derivative having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.
has effect	http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001188 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001069 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0001050 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000666 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000592 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000480 http://purl.obolibrary.org/obo/OAE_0001364
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909
has role	http://purl.obolibrary.org/obo/CHEBI_37930 http://purl.obolibrary.org/obo/CHEBI_48561
InChI	InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
InChIKey	InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_1440
is metabolised by	http://purl.obolibrary.org/obo/dinto_2993
is substrate of	http://purl.obolibrary.org/obo/dinto_2993
label	fluphenazine
may interact with	http://purl.obolibrary.org/obo/CHEBI_4469 http://purl.obolibrary.org/obo/dinto_DB00579 http://purl.obolibrary.org/obo/CHEBI_5000 http://purl.obolibrary.org/obo/CHEBI_5280 http://purl.obolibrary.org/obo/CHEBI_127342 http://purl.obolibrary.org/obo/dinto_DB01579 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/dinto_DB01578 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/CHEBI_4530 http://purl.obolibrary.org/obo/CHEBI_8067 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_3181 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_8080 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/dinto_DB00397 http://purl.obolibrary.org/obo/CHEBI_27796 http://purl.obolibrary.org/obo/dinto_DB01577 http://purl.obolibrary.org/obo/CHEBI_9467 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/CHEBI_5557 http://purl.obolibrary.org/obo/CHEBI_439329 http://purl.obolibrary.org/obo/CHEBI_3044 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/CHEBI_2679
modulates	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909
prefixIRI	obo2:CHEBI_5123
prefLabel	fluphenazine
SMILES	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1 OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1
Synonym	C22H26F3N3OS 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine Fluorphenazine 2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol 4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol flufenazina 10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine 2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine Fluphenazine Triflumethazine fluphenazine Fluorfenazine 4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol fluphenazinum 10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine Fluorophenazine 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
xref	Patent:GB829246 PubChem Compound:3372 ChEBI:5123 RxList:http://www.rxlist.com/cgi/generic3/fluphen.htm PharmGKB:PA449676 CASRN:69-23-8 KEGG DRUG:D07977 Guide To Pharmacology:204 Wikipedia:Fluphenazine DrugBank:DB00623 PubChem Substance:46506645 Patent:GB833474 Drugs.com:http://www.drugs.com/cdi/fluphenazine.html IUPHAR:204 ChEMBL:136842 BindingDB:50017655 Gmelin:1231182 Beilstein:61643 ChemSpider:3255 Wikipedia:http://en.wikipedia.org/wiki/Fluphenazine Drugs Product Database (DPD):2244166 Beilstein:1189506 KEGG COMPOUND:C07010 Patent:US3194733 National Drug Code Directory:0003-0801-10 CiteXplore:1650428 CiteXplore:5128930 NIST Chemistry WebBook:69-23-8 Patent:US3058979
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_5123	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	FYPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	INBANCIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	FYPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5123	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	FYPO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D005476	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147853	NDFRT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147853	INBANCIDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147853	CIDO	LOOM
http://purl.bioontology.org/ontology/VANDF/4019762	VANDF	LOOM
http://purl.bioontology.org/ontology/RCD/x004h	RCD	LOOM
http://purl.bioontology.org/ontology/SNMI/C-62A20	SNMI	LOOM
http://purl.bioontology.org/ontology/LNC/LP16152-8	LOINC	LOOM
http://www.drugbank.ca/drugs/DB00623	FTC	LOOM
http://www.case.edu/EpilepsyOntology.owl#Fluphenazine	EPSO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47536	NCIT	LOOM
https://go.drugbank.com/drugs/DB00623	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5133	OCHV	LOOM
http://purl.bioontology.org/ontology/NDDF/001473	NDDF	LOOM
http://purl.bioontology.org/ontology/ATC/N05AB02	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_5123	FYPO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.369.326	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Fluphenazine	GALEN	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372730004	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/MESH_D005476	BERO	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass1ba036ea_cd34_4f5c_825f_7a4458060356	WWECA	LOOM
http://purl.obolibrary.org/obo/NCIT_C47536	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D005476	MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0006685	OMIT	LOOM
http://purl.jp/bio/4/id/200906076338832918	IOBC	LOOM
http://www.case.edu/EpSO.owl#Fluphenazine	MEPO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017394	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/CSP/2264-5314	CRISP	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060471	LOINC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0016368	OCHV	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Fluphenazine	APAONTO	LOOM
http://purl.bioontology.org/ontology/RXNORM/4496	RXNORM	LOOM
http://stirdf.jst.go.jp/id/200907036971811298	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.741.326	RH-MESH	LOOM