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The Drug-Drug Interactions Ontology
| Preferred Name | fenfluramine | |
| Synonyms |
2-ethylamino-1-(3-trifluoromethylphenyl)propane fenfluraminum (+-)-fenfluramine N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane 3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine fenfluramine Fenfluramine C12H16F3N N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_5000 |
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| activates | ||
| altId |
CHEBI:239434
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|
| ATCCode |
A08AA04 A08AA02
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|
| binds |
http://purl.obolibrary.org/obo/dinto_2714 http://purl.obolibrary.org/obo/dinto_2993 |
|
| CASRN |
458-24-2
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|
| DBBrand |
pondimin rotondin ponderex ponderax pa pesos obedrex acino adipomin
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|
| DBname |
fenfluramine
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|
| DBSynonym |
fenfluraminum [inn-latin] dea no. 1670 fenfluramine hydrochloride fenfluramina [dcit]
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|
| Definition |
1-Phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
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|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_2714 |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_50949 |
|
| InChI |
InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
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|
| InChIKey |
InChIKey=DBGIVFWFUFKIQN-UHFFFAOYSA-N
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|
| inhibits | ||
| label |
fenfluramine
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|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB01307 http://purl.obolibrary.org/obo/CHEBI_9943 http://purl.obolibrary.org/obo/CHEBI_31981 http://purl.obolibrary.org/obo/dinto_DB00902 http://purl.obolibrary.org/obo/CHEBI_6838 http://purl.obolibrary.org/obo/CHEBI_8028 http://purl.obolibrary.org/obo/CHEBI_7936 http://purl.obolibrary.org/obo/dinto_DB01306 http://purl.obolibrary.org/obo/CHEBI_3647 http://purl.obolibrary.org/obo/CHEBI_8491 http://purl.obolibrary.org/obo/CHEBI_9711 http://purl.obolibrary.org/obo/dinto_DB01246 http://purl.obolibrary.org/obo/CHEBI_45951 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/dinto_DB00780 http://purl.obolibrary.org/obo/CHEBI_8459 http://purl.obolibrary.org/obo/CHEBI_5123 http://purl.obolibrary.org/obo/CHEBI_2401 http://purl.obolibrary.org/obo/CHEBI_5138 http://purl.obolibrary.org/obo/CHEBI_8461 http://purl.obolibrary.org/obo/CHEBI_8435 http://purl.obolibrary.org/obo/dinto_DB01247 http://purl.obolibrary.org/obo/dinto_DB00752 http://purl.obolibrary.org/obo/CHEBI_5557 http://purl.obolibrary.org/obo/CHEBI_63620 http://purl.obolibrary.org/obo/CHEBI_313639 http://purl.obolibrary.org/obo/CHEBI_9544 |
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| modulates | ||
| prefixIRI |
obo2:CHEBI_5000
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|
| prefLabel |
fenfluramine
|
|
| SMILES |
CCNC(C)CC1=CC(=CC=C1)C(F)(F)F CCNC(C)Cc1cccc(c1)C(F)(F)F
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|
| Synonym |
2-ethylamino-1-(3-trifluoromethylphenyl)propane fenfluraminum (+-)-fenfluramine N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane 3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine fenfluramine Fenfluramine C12H16F3N N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine
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|
| xref |
KEGG COMPOUND:C06996 DrugBank:DB00574 Wikipedia:http://en.wikipedia.org/wiki/Fenfluramine PubChem Compound:3337 NIST Chemistry WebBook:458-24-2 RxList:http://www.rxlist.com/cgi/generic/fenflur.htm Patent:US3198833 PharmGKB:PA449592 Drugs Product Database (DPD):1914057 Beilstein:2109374 CASRN:458-24-2 ChemSpider:3220 KEGG DRUG:D07945 ChEBI:5000 PubChem Substance:46506096
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| subClassOf |
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