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The Drug-Drug Interactions Ontology
| Preferred Name | droperidol | |
| Synonyms |
droperidolum 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone C22H22FN3O2 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one droperidol 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_4717 |
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| AHFScode |
28:24.92
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| altId |
CHEBI:252751
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| ATCCode |
N05AD08
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| binds | ||
| blocks | ||
| CASRN |
548-73-2
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| DBBrand |
sintodril innovan droleptan inoval innovar inopsin innovar-vet mcn-jr 4749 dhbp dehydrobenzperidol vetkalm inapsin thalamonal leptanal halkan properidol deidrobenzperidolo thalamanol inappin leptofen inapsine sintosian dridol dihidrobenzperidol dehidrobenzperidol
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| DBname |
droperidol
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|
| Definition |
An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
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| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0001064 http://purl.obolibrary.org/obo/OAE_0000677 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000355 |
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| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_65190 http://purl.obolibrary.org/obo/CHEBI_50919 |
|
| InChI |
InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
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| InChIKey |
InChIKey=RMEDXOLNCUSCGS-UHFFFAOYSA-N
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|
| label |
droperidol
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| may interact with |
http://purl.obolibrary.org/obo/dinto_DB01551 http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/CHEBI_3216 http://purl.obolibrary.org/obo/CHEBI_3419 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_3175 http://purl.obolibrary.org/obo/CHEBI_3242 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_27796 http://purl.obolibrary.org/obo/CHEBI_9467 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/dinto_DB01369 |
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| modulates | ||
| prefixIRI |
obo2:CHEBI_4717
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|
| prefLabel |
droperidol
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|
| SMILES |
FC1=CC=C(C=C1)C(=O)CCCN1CCC(=CC1)N1C(=O)NC2=CC=CC=C12 Fc1ccc(cc1)C(=O)CCCN1CCC(=CC1)n1c2ccccc2[nH]c1=O
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| Synonym |
droperidolum 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone C22H22FN3O2 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one droperidol 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
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| xref |
PubChem Compound:3168 Wikipedia:Droperidol CASRN:548-73-2 BindingDB:50017705 DrugBank:DB00450 Drugs Product Database (DPD):2167832 ChEBI:4717 KEGG DRUG:D00308 PharmGKB:PA449422 Wikipedia:http://en.wikipedia.org/wiki/Droperidol RxList:http://www.rxlist.com/cgi/generic3/droperidol.htm PubChem Substance:46505291 Patent:US3161645 Drugs.com:http://www.drugs.com/cdi/droperidol.html Beilstein:579168 National Drug Code Directory:11098-010-01 ChemSpider:3056
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| subClassOf |
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