The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	trifluoperazine
Synonyms	trifluoperazina trifluperazine trifluoperazine 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine C21H24F3N3S trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine trifluoperazinum trifluoroperazine Trifluoperazine 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
ID	http://purl.obolibrary.org/obo/CHEBI_45951
AHFScode	28:16.08.24
altId	CHEBI:9709 CHEBI:45949
ATCCode	N05AB06
binds	http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_0450 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3611 http://purl.obolibrary.org/obo/dinto_1941 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_3323 http://purl.obolibrary.org/obo/dinto_0234 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0270
blocks	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_3323 http://purl.obolibrary.org/obo/dinto_0234
CASRN	117-89-5
DBBrand	terfluzine jatroneural triperazine triftazin stellazine fluoperazine triflurin triphthazine modalina eskazine novo-trifluzine stelazine triphtazine triphthasine synklor eskazinyl tryptazine triphtazin trazine triftazine
DBname	trifluoperazine
DBSynonym	trifluoperazina trifluoromethylperazine trifluperazine trifluoperazine dihydrochloride triphthazine dihydrochloride trifluoperazine hcl tryptazine dihydrochloride trifluoperazin trifluoroperazine dihydrochloride trifluoroperazine trifluroperizine trifluoperazine hydrochloride trifluoroperazine hydrochloride
Definition	A phenothiazine derivative having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001188 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0001431 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0001069 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000642 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000995 http://purl.obolibrary.org/obo/OAE_0001050 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000592 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000275 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000480 http://purl.obolibrary.org/obo/OAE_0000811
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_3323 http://purl.obolibrary.org/obo/dinto_0234
has role	http://purl.obolibrary.org/obo/CHEBI_37930 http://purl.obolibrary.org/obo/CHEBI_50919 http://purl.obolibrary.org/obo/CHEBI_48561
InChI	InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
InChIKey	InChIKey=ZEWQUBUPAILYHI-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_0450 http://purl.obolibrary.org/obo/dinto_1440
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0270
is substrate of	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0270
label	trifluoperazine
may interact with	http://purl.obolibrary.org/obo/CHEBI_4469 http://purl.obolibrary.org/obo/dinto_DB00579 http://purl.obolibrary.org/obo/CHEBI_5000 http://purl.obolibrary.org/obo/CHEBI_5280 http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB01579 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/dinto_DB01578 http://purl.obolibrary.org/obo/CHEBI_8874 http://purl.obolibrary.org/obo/CHEBI_4530 http://purl.obolibrary.org/obo/CHEBI_8067 http://purl.obolibrary.org/obo/CHEBI_53289 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_3181 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_8080 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/dinto_DB00397 http://purl.obolibrary.org/obo/CHEBI_27796 http://purl.obolibrary.org/obo/dinto_DB01577 http://purl.obolibrary.org/obo/CHEBI_9467 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/CHEBI_5557 http://purl.obolibrary.org/obo/CHEBI_45979 http://purl.obolibrary.org/obo/CHEBI_439329 http://purl.obolibrary.org/obo/CHEBI_3044 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/CHEBI_2679
modulates	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_3323 http://purl.obolibrary.org/obo/dinto_0234
prefixIRI	obo2:CHEBI_45951
prefLabel	trifluoperazine
related with	http://purl.obolibrary.org/obo/dinto_3611 http://purl.obolibrary.org/obo/dinto_1941
SMILES	CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1 CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1
Synonym	trifluoperazina trifluperazine trifluoperazine 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine C21H24F3N3S trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine trifluoperazinum trifluoroperazine Trifluoperazine 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
xref	PharmGKB:PA451771 BindingDB:50001886 ChemSpider:5365 Beilstein:57272 CASRN:117-89-5 Guide To Pharmacology:214 RxList:http://www.rxlist.com/cgi/generic3/trifluo.htm PubChem Compound:5566 PDB:TFP ChEMBL:101325 Drugs Product Database (DPD):776505 PDBeChem:TFP Wikipedia:Trifluoperazine KEGG DRUG:D08636 PubChem Substance:46507961 IUPHAR:214 NIST Chemistry WebBook:117-89-5 DrugBank:DB00831 Gmelin:2415561 National Drug Code Directory:0378-2401-01 ChEBI:45951 CiteXplore:1650428 Drugs.com:http://www.drugs.com/cdi/trifluoperazine.html Wikipedia:http://en.wikipedia.org/wiki/Trifluoperazine PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tri1412.shtml KEGG COMPOUND:C07168
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_45951	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	BAO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	FYPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_45951	DRON	SAME_URI
http://purl.bioontology.org/ontology/RCD/x02LW	RCD	LOOM
http://purl.bioontology.org/ontology/MESH/D014268	MESH	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003230	LOINC	LOOM
http://purl.obolibrary.org/obo/OMIT_0015106	OMIT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373524005	SNOMEDCT	LOOM
http://www.case.edu/EpSO.owl#Trifluoperazine	MEPO	LOOM
https://go.drugbank.com/drugs/DB00831	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/10800	RXNORM	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass3423b585_318c_4015_b129_6abf444c2082	WWECA	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040979	OCHV	LOOM
http://purl.bioontology.org/ontology/ATC/N05AB06	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	BAO	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_45951	DRON	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12555	OCHV	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017406	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/VANDF/4019957	VANDF	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148042	NDFRT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.741.898	RH-MESH	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Trifluoperazine	APAONTO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.369.898	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Trifluoperazine	GALEN	LOOM
http://www.case.edu/EpilepsyOntology.owl#Trifluoperazine	EPSO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62084	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014268	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D014268	BERO	LOOM
http://www.drugbank.ca/drugs/DB00831	FTC	LOOM
http://stirdf.jst.go.jp/id/200907007388858170	IOBC	LOOM
http://purl.jp/bio/4/id/200906018380266000	IOBC	LOOM
http://purl.obolibrary.org/obo/NCIT_C62084	BERO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-62A60	SNMI	LOOM
http://purl.bioontology.org/ontology/LNC/LP16299-7	LOINC	LOOM