The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	hydroxyurea
Synonyms	hydroxycarbamidum hydroxycarbamide Hydroxycarbamide Hydroxycarbamid N-carbamoylhydroxylamine Hydroxyurea N-HYDROXYUREA hydrea carbamoyl oxime CH4N2O2 carbamohydroxamic acid N-hydroxyurea oxyurea carbamohydroximic acid hidroxicarbamida Hydroxyharnstoff hydroxyurea carbamyl hydroxamate
ID	http://purl.obolibrary.org/obo/CHEBI_44423
AHFScode	10:00.00
altId	CHEBI:5816 CHEBI:44420
ATCCode	L01XX05
binds	http://purl.obolibrary.org/obo/dinto_1599 http://purl.obolibrary.org/obo/dinto_2993
CASRN	127-07-1
DBBrand	hydurea hidrix litaler onco-carbide hydrea droxia hydura oxyurea hydreia biosupressin litalir ureaphil
DBname	hydroxyurea
DBSynonym	hydroxycarbamine hydroxycarbamide idrossicarbamide [dcit] hu carbamoyl oxime carbamohydroxamic acid hydroxicarbamidum carbamohydroximic acid hydroxylurea n-hydroxyurea carbamohydroxyamic acid n-carbamoylhydroxylamine carbamyl hydroxamate
Definition	A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001397 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0001485 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0000687 http://purl.obolibrary.org/obo/OAE_0000943 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000752 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0001145 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0001364
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1599
has role	http://purl.obolibrary.org/obo/CHEBI_50905 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_50846 http://purl.obolibrary.org/obo/CHEBI_59517 http://purl.obolibrary.org/obo/CHEBI_35221 http://purl.obolibrary.org/obo/CHEBI_50902 http://purl.obolibrary.org/obo/CHEBI_64911 http://purl.obolibrary.org/obo/CHEBI_74213 http://purl.obolibrary.org/obo/CHEBI_48578
InChI	InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChIKey	InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1599 http://purl.obolibrary.org/obo/dinto_2993
label	hydroxyurea
prefixIRI	obo2:CHEBI_44423
prefLabel	hydroxyurea
SMILES	NC(=O)NO
Synonym	hydroxycarbamidum hydroxycarbamide Hydroxycarbamide Hydroxycarbamid N-carbamoylhydroxylamine Hydroxyurea N-HYDROXYUREA hydrea carbamoyl oxime CH4N2O2 carbamohydroxamic acid N-hydroxyurea oxyurea carbamohydroximic acid hidroxicarbamida Hydroxyharnstoff hydroxyurea carbamyl hydroxamate
xref	CiteXplore:11285159 CiteXplore:11391710 CiteXplore:22983419 RxList:http://www.rxlist.com/cgi/generic2/hydroxyurea.htm HMDB:HMDB15140 PDBeChem:NHY CiteXplore:11298103 Drugs.com:http://www.drugs.com/cdi/hydroxyurea.html Wikipedia:http://en.wikipedia.org/wiki/Hydroxyurea CiteXplore:11365149 CiteXplore:15994344 CiteXplore:9271088 PubChem Substance:46506927 CiteXplore:15772364 CiteXplore:12107454 DrugBank:DB01005 KEGG DRUG:D00341 KEGG COMPOUND:C07044 PubChem Compound:3657 ChemSpider:3530 ChEMBL:104730 PharmGKB:PA449942 CiteXplore:23696560 Patent:US2705727 MetaCyc:HYDROXY-UREA CiteXplore:16356682 National Drug Code Directory:0555-0882-02 CiteXplore:14988684 CiteXplore:11364534 ChEBI:5816 Wikipedia:Hydroxyurea Drugs Product Database (DPD):2247937 CiteXplore:23318979 Gmelin:130423 CiteXplore:23643402 CASRN:1741548 CASRN:127-07-1
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_44423	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	UPHENO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	FYPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	ECTO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	MCO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423	ODNAE	SAME_URI
http://purl.bioontology.org/ontology/PDQ/CDR0000040685	PDQ	LOOM
rgo:15179	GAMUTS	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6391	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C560	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146101	NDFRT	LOOM
http://www.co-ode.org/ontologies/galen#Hydroxyurea	GALEN	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017548	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/SCDO_0000580	SCDO	LOOM
http://www.drugbank.ca/drugs/DB01005	FTC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.395	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D006918	BERO	LOOM
https://go.drugbank.com/drugs/DB01005	MDM	LOOM
http://purl.bioontology.org/ontology/MESH/D006918	MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0008052	OMIT	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	MCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_44423	ODNAE	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020402	OCHV	LOOM
http://purl.jp/bio/4/id/200906063694062928	IOBC	LOOM
http://purl.bioontology.org/ontology/RXNORM/5552	RXNORM	LOOM
http://purl.bioontology.org/ontology/VANDF/4017733	VANDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560	NCIT	LOOM
http://purl.bioontology.org/ontology/CSP/0113-4000	CRISP	LOOM
http://purl.bioontology.org/ontology/NDDF/002635	NDDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006918	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78100	SNMI	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387314007	SNOMEDCT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146101	ODAE	LOOM
http://stirdf.jst.go.jp/id/200907035920979546	IOBC	LOOM
http://purl.bioontology.org/ontology/RCD/h55..	RCD	LOOM