The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	dexamethasone
Synonyms	dexamethasonum 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol 9alpha-Fluoro-16alpha-methylprednisolone (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one Dexamethasone C22H29FO5 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone Decadron dexamethasone dexametasona
ID	http://purl.obolibrary.org/obo/CHEBI_41879
activates	http://purl.obolibrary.org/obo/dinto_2874 http://purl.obolibrary.org/obo/dinto_0764 http://purl.obolibrary.org/obo/dinto_0955
AHFScode	52:08.08 68:04.00
altId	CHEBI:4461 CHEBI:41873
ATCCode	D07XB05 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01 D10AA03 H02AB02 A01AC02 C05AA09 D07AB19
binds	http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1559 http://purl.obolibrary.org/obo/dinto_0266 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0076 http://purl.obolibrary.org/obo/dinto_3102 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0762 http://purl.obolibrary.org/obo/dinto_0456 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465 http://purl.obolibrary.org/obo/dinto_2874 http://purl.obolibrary.org/obo/dinto_0764 http://purl.obolibrary.org/obo/dinto_0955
CASRN	50-02-2
DBBrand	dex-ide hexadrol tablets dexa-mamallet spoloven dergramin mediamethasone maxidex dextelan ocu-trol oradexon decadron tablets, elixir dekacort dexalona fortecortin dexa azium dexone 0.75 aphtasolon dezone dexinoral dexone 1.5 lokalison f dexason dexacortal corson decaderm adexone dectancyl hexadecadrol dexapos dinormon decalix dexa-cortisyl dexacort dexaprol deseronil dexone decacort luxazone gammacorten anaflogistico dexamethasone intensol mymethasone policort decadron decadron-la dexacortin decaspray dexamonozon dexone 0.5 loverine turbinaire dexa-cortidelt auxiron fluormone cortisumman dexafarma deronil corsone aeroseb-dex dexadeltone pet derm iii dexa mamallet dexa-scheroson dexameth sunia sol d deltafluorene dexa-sine iontodex prednisolone f dexonium sk-dexamethasone superprednol aeroseb-d aphthasolone dexone 4 decasone isopto-dex visumetazone bisu ds pet-derm iii hexadrol elixir hexadrol dexapolcort decagel dexaltin prednisolon f dexasone mexidex dexinolon desadrene desameton posurdex calonat hl-dex decacortin fluorocort millicorten
DBname	dexamethasone
DBSynonym	desamethasone dexamethazone dexamethasonum [inn-latin] dexamethasone acetate dexamethasone sodium phosphate desametasone fluormethylprednisolone desametasone [dcit] dexametasona [inn-spanish]
Definition	A fluorinated steroid that has formula C22H29FO5.
has effect	http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000838 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001259 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000489 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0001280 http://purl.obolibrary.org/obo/OAE_0001397 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001073 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001468 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0001101 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001070 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0001291 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001035
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2874
has role	http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_37962 http://purl.obolibrary.org/obo/CHEBI_50919 http://purl.obolibrary.org/obo/CHEBI_35472
InChI	InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey	InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N
induces	http://purl.obolibrary.org/obo/dinto_3102 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0762 http://purl.obolibrary.org/obo/dinto_0456 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
inhibits	http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1559 http://purl.obolibrary.org/obo/dinto_0266 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440
is metabolised by	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956
is substrate of	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1440
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	dexamethasone
may interact with	http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB01399 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_49960 http://purl.obolibrary.org/obo/dinto_DB08864 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_9939 http://purl.obolibrary.org/obo/dinto_DB00306 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/CHEBI_499361 http://purl.obolibrary.org/obo/dinto_DB01355 http://purl.obolibrary.org/obo/dinto_DB01397 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/dinto_DB01122 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/CHEBI_15365 http://purl.obolibrary.org/obo/CHEBI_9513 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB06287 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_2654 http://purl.obolibrary.org/obo/dinto_DB01354 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB00545 http://purl.obolibrary.org/obo/CHEBI_47657 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB01352 http://purl.obolibrary.org/obo/CHEBI_7514 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/dinto_DB08866 http://purl.obolibrary.org/obo/CHEBI_6933 http://purl.obolibrary.org/obo/CHEBI_251408 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00072 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB01353 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/dinto_DB01341 http://purl.obolibrary.org/obo/CHEBI_9073 http://purl.obolibrary.org/obo/CHEBI_70735 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_45783
modulates	http://purl.obolibrary.org/obo/dinto_2874 http://purl.obolibrary.org/obo/dinto_0764 http://purl.obolibrary.org/obo/dinto_0955
prefixIRI	obo2:CHEBI_41879
prefLabel	dexamethasone
related with	http://purl.obolibrary.org/obo/dinto_0076
SMILES	[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Synonym	dexamethasonum 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol 9alpha-Fluoro-16alpha-methylprednisolone (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one Dexamethasone C22H29FO5 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone Decadron dexamethasone dexametasona
xref	CASRN:50-02-2 KEGG DRUG:D00292 Patent:GB869511 BindingDB:18207 DrugBank:DB01234 Wikipedia:http://en.wikipedia.org/wiki/Dexamethasone Patent:US3007923 IUPHAR:2768 Drugs Product Database (DPD):664227 PubChem Substance:46508930 National Drug Code Directory:0703-3524-03 RxList:http://www.rxlist.com/cgi/generic/dexameth.htm PharmGKB:PA449247 ChemSpider:5541 ChEBI:41879 Drugs.com:http://www.drugs.com/cdi/dexamethasone-drops.html PubChem Compound:5743 PDB:DEX PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dec1118.shtml Guide To Pharmacology:2768 ChEMBL:465281 Beilstein:2066652 Wikipedia:Dexamethasone Patent:DE1113690
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_41879	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	HSPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	ECTO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	HINO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41879	OBA	LOOM
http://purl.obolibrary.org/obo/XCO_0000372	XCO	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039789	PDQ	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	HSPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	HINO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41879	ODNAE	LOOM
http://purl.obolibrary.org/obo/OMIT_0005183	OMIT	LOOM
http://purl.bioontology.org/ontology/LNC/LP18549-3	LOINC	LOOM
http://purl.bioontology.org/ontology/RCD/x02M3	RCD	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C422	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.908.238	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/S03BA01	ATC	LOOM
http://purl.jp/bio/4/id/200906065294692755	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/A01AC02	ATC	LOOM
http://www.drugbank.ca/drugs/DB01234	FTC	LOOM
http://purl.bioontology.org/ontology/CSP/0059-7733	CRISP	LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Dexamethasone	SEPON	LOOM
http://purl.bioontology.org/ontology/ATC/S01CB01	ATC	LOOM
http://purl.bioontology.org/ontology/ATC/D07XB05	ATC	LOOM
http://purl.bioontology.org/ontology/MESH/D003907	MESH	LOOM
http://purl.bioontology.org/ontology/ATC/R01AD03	ATC	LOOM
http://purl.bioontology.org/ontology/ATC/D10AA03	ATC	LOOM
http://purl.bioontology.org/ontology/ATC/D07AB19	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.432.769.344	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP32530-5	LOINC	LOOM
http://stirdf.jst.go.jp/id/200907013999102683	IOBC	LOOM
http://purl.bioontology.org/ontology/RXNORM/3264	RXNORM	LOOM
http://purl.bioontology.org/ontology/ATC/C05AA09	ATC	LOOM
http://purl.bioontology.org/ontology/ATC/S01BA01	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D003907	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3823	OCHV	LOOM
http://purl.bioontology.org/ontology/ATC/S02BA06	ATC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146273	NDFRT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018691	PMAPP-PMO	LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571353432175145010	ACVD_ONTOLOGY	LOOM
https://go.drugbank.com/drugs/DB01234	MDM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003907	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372584003	SNOMEDCT	LOOM
http://www.co-ode.org/ontologies/galen#Dexamethasone	GALEN	LOOM
http://purl.bioontology.org/ontology/ATC/H02AB02	ATC	LOOM
http://purl.obolibrary.org/obo/NCIT_C422	BERO	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00743	COID	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_eac7fb6f_58b2_49c0_b6cc_a4436375cf48	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_eac7fb6f_58b2_49c0_b6cc_a4436375cf48	CVAO	LOOM
http://purl.bioontology.org/ontology/VANDF/4017922	VANDF	LOOM
http://bmi.utah.edu/ontologies/peontology/C0011777	RAO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146273	ODAE	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00317	OCIMIDO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004621	LOINC	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Dexamethasone	APAONTO	LOOM