The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	lovastatin
Synonyms	ML-530B Mevinolin (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate LOVASTATIN 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone C24H36O5 Lovastatin (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate 6alpha-methylcompactin (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate Mevacor MK-803
ID	http://purl.obolibrary.org/obo/CHEBI_40303
AHFScode	24:06.08
altId	CHEBI:6544 CHEBI:40299
ATCCode	C10AA02
binds	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_4019 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0185 http://purl.obolibrary.org/obo/dinto_3000 http://purl.obolibrary.org/obo/dinto_1890 http://purl.obolibrary.org/obo/dinto_1892 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0426 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0276 http://purl.obolibrary.org/obo/dinto_0887
CASRN	75330-75-5
DBBrand	hipolip lestatin nergadan altocor lovalord tecnolip rovacor lovasterol lipdip lovastin mevlor mevinacor lovalip mevacor artein monacolin k lozutin sivlor rodatin altoprev lipofren colevix teroltrat hipovastin belvas taucor cholestra lipivas paschol closterol
DBname	lovastatin
DBSynonym	lovastatine [french] lovastatina [spanish] lovastatinum [latin] 6 alpha-methylcompactin
Definition	A fatty acid ester that has formula C24H36O5.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000205 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001378 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001024 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0001205 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001030 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_4019
has role	http://purl.obolibrary.org/obo/CHEBI_35664 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_35679
InChI	InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
InChIKey	InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N
induces	http://purl.obolibrary.org/obo/dinto_2058
inhibits	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_4019 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1221
is metabolised by	http://purl.obolibrary.org/obo/dinto_1890 http://purl.obolibrary.org/obo/dinto_1892 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0426 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0276
is substrate of	http://purl.obolibrary.org/obo/dinto_1890 http://purl.obolibrary.org/obo/dinto_1892 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0426 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0276 http://purl.obolibrary.org/obo/dinto_0887
is transported by	http://purl.obolibrary.org/obo/dinto_0887
label	lovastatin
may interact with	http://purl.obolibrary.org/obo/CHEBI_119486 http://purl.obolibrary.org/obo/CHEBI_5001 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/CHEBI_5296 http://purl.obolibrary.org/obo/CHEBI_4315 http://purl.obolibrary.org/obo/CHEBI_68558 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_2955 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/dinto_DB01394 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_7494 http://purl.obolibrary.org/obo/CHEBI_68595 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_15940 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_45367 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/CHEBI_47612 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_51450 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_31739 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_367163 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_72297 http://purl.obolibrary.org/obo/CHEBI_63613 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_45783
prefixIRI	obo2:CHEBI_40303
prefLabel	lovastatin
related with	http://purl.obolibrary.org/obo/dinto_0185 http://purl.obolibrary.org/obo/dinto_3000
SMILES	[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC
Synonym	ML-530B Mevinolin (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate LOVASTATIN 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone C24H36O5 Lovastatin (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate 6alpha-methylcompactin (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate Mevacor MK-803
xref	Wikipedia:Lovastatin IUPHAR:2739 PubChem Substance:46508223 ChemSpider:48085 Guide To Pharmacology:2739 KEGG COMPOUND:C07074 CASRN:3631989 National Drug Code Directory:0378-6510-91 Drugs.com:http://www.drugs.com/cdi/lovastatin.html PharmGKB:PA450272 RxList:http://www.rxlist.com/cgi/generic3/altocor.htm ChEBI:40303 PDBeChem:803 PDB:803 KEGG DRUG:D00359 ChEMBL:109495 Wikipedia:http://en.wikipedia.org/wiki/Lovastatin Drugs Product Database (DPD):2243127 CASRN:75330-75-5 DrugBank:DB00227 PubChem Compound:53232
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_40303	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	FYPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	DIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_40303	OBA	LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571353432175145082	ACVD_ONTOLOGY	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.400	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7547	OCHV	LOOM
http://www.semanticweb.org/ontologies/STO.owl#ad676_f06b_41b6_bce5_c0654ae7704f	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#ad676_f06b_41b6_bce5_c0654ae7704f	CVAO	LOOM
http://purl.bioontology.org/ontology/MESH/D008148	MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016942	PMAPP-PMO	LOOM
http://www.drugbank.ca/drugs/DB00227	FTC	LOOM
http://www.co-ode.org/ontologies/galen#Lovastatin	GALEN	LOOM
http://www.owl-ontologies.com/OntologyXCT.owl#Lovastatin	CTX	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C620	NCIT	LOOM
http://purl.bioontology.org/ontology/LNC/LP171620-0	LOINC	LOOM
http://stirdf.jst.go.jp/id/200907051916473544	IOBC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147602	NDFRT	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	DIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	ODNAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_40303	OBA	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.400	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0009229	OMIT	LOOM
http://purl.bioontology.org/ontology/NDDF/002063	NDDF	LOOM
https://go.drugbank.com/drugs/DB00227	MDM	LOOM
http://purl.bioontology.org/ontology/ATC/C10AA02	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008148	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4019482	VANDF	LOOM
http://purl.jp/bio/4/id/200906081671822761	IOBC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041658	PDQ	LOOM
http://purl.obolibrary.org/obo/MESH_D008148	BERO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147602	ODAE	LOOM
http://purl.bioontology.org/ontology/CSP/1991-4266	CRISP	LOOM
http://purl.bioontology.org/ontology/SNMI/C-80810	SNMI	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0024027	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/6472	RXNORM	LOOM
http://purl.obolibrary.org/obo/NCIT_C620	BERO	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02124	MIO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96303004	SNOMEDCT	LOOM