The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	cyclophosphamide
Synonyms	(RS)-Cyclophosphamide (+-)-Cyclophosphamide C7H15Cl2N2O2P Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide Cyclophosphamide anhydrous 2-[bis(2-chloroethyl)amino]-1,3,2$l^{5}-oxazaphosphinan-2-one N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
ID	http://purl.obolibrary.org/obo/CHEBI_4027
AHFScode	10:00.00
ATCCode	L01DB07 L01AA01
binds	http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1959
CASRN	50-18-0
DBBrand	asta endoxan neosar genoxal cytophosphan endoxan-asta hexadrin cytoxan lyoph cyclophosphamidum semdoxan cytoxan sendoxan endoxana enduxan rcra waste number u058 endoxanal cyklofosfamid lyophilized cytoxan cyclophosphan cyclophosphamide sterile cy endoxan r asta b 518 endoxane cyclophosphamid cyclostin cyclophosphamide monohydrate procytox revimmune claphene senduxan cyclophosphane cyclophosphoramide mitoxan clafen zyklophosphamid
DBname	cyclophosphamide
DBSynonym	neosar cytoxan cpm cyt ctx
Definition	A cyclic phosphorodiamide-based nitrogen mustard.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0001273 http://purl.obolibrary.org/obo/OAE_0000882 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0001046 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000913 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001012 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001397 http://purl.obolibrary.org/obo/OAE_0000264 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001378 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0001485 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000353 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000943 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001425 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001443 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000275 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000466 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001035 http://purl.obolibrary.org/obo/OAE_0000488 http://purl.obolibrary.org/obo/OAE_0000456 http://purl.obolibrary.org/obo/OAE_0001366 http://purl.obolibrary.org/obo/OAE_0001364
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2873
has role	http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_22333 http://purl.obolibrary.org/obo/CHEBI_50903 http://purl.obolibrary.org/obo/CHEBI_35842
InChI	InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)
InChIKey	InChIKey=CMSMOCZEIVJLDB-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
inhibits	http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
is substrate of	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
label	cyclophosphamide
may interact with	http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/dinto_DB00552 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_45652 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB04572 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00072
prefixIRI	obo2:CHEBI_4027
prefLabel	cyclophosphamide
related with	http://purl.obolibrary.org/obo/dinto_2873
SMILES	ClCCN(CCCl)P1(=O)NCCCO1
Synonym	(RS)-Cyclophosphamide (+-)-Cyclophosphamide C7H15Cl2N2O2P Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide Cyclophosphamide anhydrous 2-[bis(2-chloroethyl)amino]-1,3,2$l^{5}-oxazaphosphinan-2-one N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
xref	ChemSpider:2804 CASRN:50-18-0 PubChem Substance:46505441 PubChem Compound:2907 ChEBI:4027 KEGG COMPOUND:C07888 PharmGKB:PA449165 Wikipedia:Cyclophosphamide PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cyt1112.shtml NIST Chemistry WebBook:50-18-0 DrugBank:DB00531 Beilstein:11744 ChEMBL:108417 Drugs.com:http://www.drugs.com/cdi/cyclophosphamide.html Wikipedia:http://en.wikipedia.org/wiki/Cyclophosphamide RxList:http://www.rxlist.com/cgi/generic3/cyclophosphamide.htm National Drug Code Directory:0054-4129-25 Drugs Product Database (DPD):2241797
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_4027	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	DOID	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	HHEAR	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	ECTO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027	OBA	LOOM
http://purl.obolibrary.org/obo/XCO_0000825	XCO	LOOM
http://purl.obolibrary.org/obo/XCO_0000825	XCO	LOOM
http://www.co-ode.org/ontologies/galen#Cyclophosphamide	GALEN	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C405	NCIT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C405	ROO	LOOM
http://purl.bioontology.org/ontology/CSP/1371-8600	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.526.728.650.730.243	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003520	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP70366-7	LOINC	LOOM
http://scai.fraunhofer.de/MSOntology#Cyclophosphamide	MSO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017036	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	DOID	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	HHEAR	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4027	OBA	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78070	SNMI	LOOM
http://bmi.utah.edu/ontologies/peontology/C0010583	RAO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3529	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/3002	RXNORM	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387420009	SNOMEDCT	LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_4027	NPO	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00180	OCIMIDO	LOOM
http://doe-generated-ontology.com/OntoPneumo#Cyclophosphamide	ONTOPNEUMO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU029970	LOINC	LOOM
https://go.drugbank.com/drugs/DB00531	MDM	LOOM
http://purl.obolibrary.org/obo/NCIT_C405	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146452	NDFRT	LOOM
http://purl.bioontology.org/ontology/ATC/L01AA01	ATC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039748	PDQ	LOOM
http://purl.bioontology.org/ontology/VANDF/4018114	VANDF	LOOM
http://purl.bioontology.org/ontology/RCD/h14..	RCD	LOOM
http://purl.bioontology.org/ontology/MESH/D003520	MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0004808	OMIT	LOOM
http://localhost/plosthes.2017-1#6736	PLOSTHES	LOOM
http://purl.obolibrary.org/obo/MESH_D003520	BERO	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00473	COID	LOOM
rgo:20952	GAMUTS	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010583	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.672.500.243	RH-MESH	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0010583	HFO	LOOM