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The Drug-Drug Interactions Ontology
| Preferred Name | amlodipine | |
| Synonyms |
amlodipinum amlodipino C20H25ClN2O5 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate amlodipine 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Amlodipine Free Base |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_2668 |
|
| AHFScode |
24:28.08
|
|
| ATCCode |
C08CA01
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0425 http://purl.obolibrary.org/obo/dinto_0429 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_0465 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_3628 http://purl.obolibrary.org/obo/dinto_2115 |
|
| CASRN |
88150-42-9
|
|
| DBBrand |
lipinox amvaz coroval norvasc amlodis amlocard lotrel
|
|
| DBname |
amlodipine
|
|
| DBSynonym |
amlodipine besilate amlodipinum [latin] amlodipino [spanish] amlodipine free base amlodipine besylate amlodipine benzenesulfonate
|
|
| Definition |
A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
|
|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2979 |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35620 |
|
| InChI |
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
|
|
| InChIKey |
InChIKey=HTIQEAQVCYTUBX-UHFFFAOYSA-N
|
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0425 http://purl.obolibrary.org/obo/dinto_0429 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_0465 http://purl.obolibrary.org/obo/dinto_1027 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2990 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2990 |
|
| label |
amlodipine
|
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_68595 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB00382 |
|
| prefixIRI |
obo2:CHEBI_2668
|
|
| prefLabel |
amlodipine
|
|
| SMILES |
CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC
|
|
| Synonym |
amlodipinum amlodipino C20H25ClN2O5 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate amlodipine 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Amlodipine Free Base
|
|
| xref |
CiteXplore:16422032 PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam CiteXplore:8310973 Wikipedia:Amlodipine CiteXplore:21591999 CiteXplore:9156957 PubChem Substance:46507214 CASRN:88150-42-9 Reaxys:3570229 Wikipedia:http://en.wikipedia.org/wiki/Amlodipine CiteXplore:19450066 Patent:US4572909 ChEMBL:518414 National Drug Code Directory:53808-0200-1 CiteXplore:1532771 Beilstein:3570229 DrugBank:88150-42-9 KEGG COMPOUND:C06825 ChemSpider:2077 Drugs Product Database (DPD):878936 RxList:http://www.rxlist.com/cgi/generic/amlod2.htm PubChem Compound:2162 CiteXplore:1834846 ChEBI:2668 CiteXplore:7522286 Patent:EP89167 PharmGKB:PA448388 KEGG DRUG:D07450 CiteXplore:8310972 DrugBank:DB00381 Drugs.com:http://www.drugs.com/amlodipine.html
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| subClassOf |
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