loading...| Preferred Name | Mantle Cell Lymphoma | |
| Synonyms |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Mantle_Cell_Lymphoma |
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| DEFINITION |
An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA. |
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| FULL_SYN |
Mantle Zone Lymphoma MCL |
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| isDefinedBy |
An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA. |
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| label |
Mantle Cell Lymphoma |
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| prefixIRI |
Thesaurus:Mantle_Cell_Lymphoma |
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| prefLabel |
Mantle Cell Lymphoma |
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| Synonym |
Mantle Zone Lymphoma MCL |
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| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Aggressive_Non-Hodgkin_s_Lymphoma http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Mature_B-Cell_Non-Hodgkin_s_Lymphoma |