Preferred Name |
clozapine |
|
Synonyms |
|
|
Definitions |
tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent; binds several types of central nervous system receptors, and displays a unique pharmacological profile; it is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype, and also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity; agranulocytosis is a major adverse effect associated with administration of this agent. |
|
ID |
http://purl.bioontology.org/ontology/CSP/0314-4862 |
|
cui |
C0009079 |
|
definition |
tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent; binds several types of central nervous system receptors, and displays a unique pharmacological profile; it is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype, and also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity; agranulocytosis is a major adverse effect associated with administration of this agent. |
|
DID |
0314-4862 |
|
Inverse of RB | ||
notation |
0314-4862 |
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prefLabel |
clozapine |
|
tui |
T109 T121 |
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subClassOf |