loading...| Preferred Name | mast cell | |
| Synonyms |
tissue basophil histaminocyte labrocyte mastocyte |
|
| Definitions |
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000097 |
|
| comment |
Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. |
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| capable of |
http://purl.obolibrary.org/obo/GO_0002830 http://purl.obolibrary.org/obo/GO_0002660 http://purl.obolibrary.org/obo/GO_0002690 http://purl.obolibrary.org/obo/GO_0002349 |
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| capable of part of |
http://purl.obolibrary.org/obo/GO_0002830 http://purl.obolibrary.org/obo/GO_0002660 http://purl.obolibrary.org/obo/GO_0002690 http://purl.obolibrary.org/obo/GO_0002349 |
|
| database_cross_reference |
CALOHA:TS-0603 BTO:0000830 FMA:66784 |
|
| definition |
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. |
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| develops_from | ||
| functionally related to |
http://purl.obolibrary.org/obo/GO_0002830 http://purl.obolibrary.org/obo/GO_0002660 http://purl.obolibrary.org/obo/GO_0002690 http://purl.obolibrary.org/obo/GO_0002349 |
|
| has high plasma membrane amount | ||
| has part |
http://purl.obolibrary.org/obo/GO_0030141 http://purl.obolibrary.org/obo/PR_000006169 http://purl.obolibrary.org/obo/PR_000001255 |
|
| has plasma membrane part |
http://purl.obolibrary.org/obo/PR_000006169 http://purl.obolibrary.org/obo/PR_000001255 |
|
| has_exact_synonym |
histaminocyte labrocyte mastocyte |
|
| has_related_synonym |
tissue basophil |
|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim |
|
| label |
mast cell |
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| lacks_plasma_membrane_part | ||
| overlaps |
http://purl.obolibrary.org/obo/GO_0030141 http://purl.obolibrary.org/obo/PR_000006169 http://purl.obolibrary.org/obo/PR_000001255 |
|
| prefixIRI |
CL:0000097 |
|
| prefLabel |
mast cell |
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| present in taxon | ||
| treeView | ||
| subClassOf |
http://purl.obolibrary.org/obo/CL_0002274 |