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Coronavirus Infectious Disease Ontology
| Preferred Name | Ribavirin | |
| Synonyms |
ribavirinum 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide InChIKey=IWUCXVSUMQZMFG-AFCXAGJDSA-N NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 C8H12N4O5 RBV ribavirin ribavirina ribavirine 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide |
|
| Definitions |
A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses. A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. An inhibitor of HCV polymerase. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_63580 |
|
| alternative term |
ribavirinum 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide InChIKey=IWUCXVSUMQZMFG-AFCXAGJDSA-N NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 C8H12N4O5 RBV ribavirin ribavirina ribavirine 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide
|
|
| charge |
0
|
|
| chemical effective in vitro against virus | ||
| chemical has protein target |
http://purl.obolibrary.org/obo/PR_P12268 http://purl.obolibrary.org/obo/PR_P49902 http://purl.obolibrary.org/obo/PR_P20839 http://purl.obolibrary.org/obo/PR_P12823 http://purl.obolibrary.org/obo/PR_000009022 |
|
| chemical has protein target as antagonist | ||
| chemical inhibits in vitro replication of virus | ||
| chemical inhibits in vivo replication of virus | ||
| chemical inhibits protein |
http://purl.obolibrary.org/obo/PR_P20839 http://purl.obolibrary.org/obo/PR_P12823 |
|
| database_cross_reference |
ChemIDplus:892462 KEGG DRUG:D00423 PMID:22156853 Reaxys:892462 CiteXplore:22156853 KEGG DRUG:36791-04-5 CiteXplore:22052220 CAS:36791-04-5 Beilstein:892462 ChemIDplus:36791-04-5 KEGG:D00423 Wikipedia:Ribavirin PMID:22239498 CiteXplore:22052088 DrugBank:DB00811 PMID:22158703 CiteXplore:22158703 CiteXplore:22239511 CiteXplore:22220723 PMID:22220723 PMID:22212569 PMID:22212568 PMID:22212566 CiteXplore:22212572 CiteXplore:22212576 CiteXplore:22212579 PMID:22212572 PMID:22212576 PMID:22212579 PMID:22239511 CiteXplore:21827730 PMID:21827730 CiteXplore:22239498 CiteXplore:22212568 CiteXplore:22212569 CiteXplore:22212566 PMID:22052088 PMID:22052220 LINCS:LSM-5701 Drug_Central:2373 PMID:29438107
|
|
| definition source |
https://www.drugbank.ca/drugs/DB00811 PMID: 24013700; PMID: 27344959 Reference: PMID: 22555152 PMID: 27344959; PMID: 26868298; PMID: 15200845; PMID: 16837072
|
|
| formula |
C8H12N4O5
|
|
| has exact synonym |
1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide
|
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35441 http://purl.obolibrary.org/obo/CHEBI_149553 http://purl.obolibrary.org/obo/CHEBI_35221 |
|
| has_alternative_id |
CHEBI:8840
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
ribavirinum 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide InChIKey=IWUCXVSUMQZMFG-AFCXAGJDSA-N NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 C8H12N4O5 RBV ribavirin ribavirina ribavirine
|
|
| has_role | ||
| has_RxCUI |
9344
|
|
| id |
CHEBI:63580
|
|
| imported from | ||
| in subset | ||
| inchi |
InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
|
|
| inchikey |
IWUCXVSUMQZMFG-AFCXAGJDSA-N
|
|
| label |
Ribavirin ribavirin
|
|
| mass |
244.20470
|
|
| monoisotopicmass |
244.08077
|
|
| notation |
CHEBI:63580
|
|
| prefLabel |
Ribavirin
|
|
| smiles |
NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
|
|
| textual definition |
A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses. A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. An inhibitor of HCV polymerase.
|
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_140324 http://purl.obolibrary.org/obo/CHEBI_62733 http://purl.obolibrary.org/obo/CHEBI_29347 |
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