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Chemical Entities of Biological Interest Ontology
| Preferred Name | droperidol | |
| Synonyms |
droperidolum 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one droperidol 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one |
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| Definitions |
An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_4717 |
|
| charge |
0
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|
| database_cross_reference |
Wikipedia:Droperidol Drug_Central:966 LINCS:LSM-4193 KEGG:D00308 DrugBank:DB00450 CAS:548-73-2 Patent:US3161645 Beilstein:579168
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|
| definition |
An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
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| formula |
C22H22FN3O2
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| has role |
http://purl.obolibrary.org/obo/CHEBI_65190 http://purl.obolibrary.org/obo/CHEBI_50919 |
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| has_alternative_id |
CHEBI:252751
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| has_exact_synonym |
1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
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|
| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
droperidolum 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one droperidol 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
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|
| id |
CHEBI:4717
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|
| in_subset | ||
| inchi |
InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
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|
| inchikey |
RMEDXOLNCUSCGS-UHFFFAOYSA-N
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|
| label |
droperidol
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|
| mass |
379.42740
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|
| monoisotopicmass |
379.16961
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|
| notation |
CHEBI:4717
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|
| prefLabel |
droperidol
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|
| smiles |
Fc1ccc(cc1)C(=O)CCCN1CCC(=CC1)n1c2ccccc2[nH]c1=O
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|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_37143 |
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| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_37143 |
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