loading...| Preferred Name | Graves disease | |
| Synonyms |
parry disease Basedow's disease Graves' hyperthyroidism Graves' disease Basedow disease Flajani-Basedow-Graves disease toxic diffuse goiter exophthalmic goiter grave's disease exophthalmic goitre Graves disease |
|
| Definitions |
Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery. A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes ( GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). |
|
| ID |
http://www.ebi.ac.uk/efo/EFO_0004237 |
|
| database_cross_reference |
MeSH:D006111 MONDO:0005364 NANDO:2200328 MEDGEN:6677 SNOMEDCT:353295004 SNOMEDCT:267374005 MESH:D006111 UMLS:C0018213 SCTID:353295004 DOID:10719 DOID:12361 ICD9:242.0 NCIT:C3071 NCIt:C3071 |
|
| definition |
Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery. A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes ( GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). |
|
| gwas_trait |
true |
|
| has_exact_synonym |
Basedow's disease Flajani-Basedow-Graves disease toxic diffuse goiter exophthalmic goiter grave's disease Graves' disease Basedow disease exophthalmic goitre Graves disease |
|
| has_related_synonym |
parry disease Basedow's disease Graves' hyperthyroidism Graves' disease Basedow disease |
|
| id |
EFO:0004237 |
|
| in_subset | ||
| label |
Graves disease |
|
| notation |
EFO:0004237 |
|
| preferred label |
Graves disease |
|
| prefLabel |
Graves disease |
|
| see also |
https://rarediseases.info.nih.gov/diseases/6549/graves-disease |
|
| skos_exactMatch |
http://identifiers.org/medgen/6677 http://identifiers.org/mesh/D006111 http://purl.obolibrary.org/obo/NCIT_C3071 http://purl.obolibrary.org/obo/DOID_12361 http://purl.obolibrary.org/obo/EFO_0004237 |
|
| term editor |
Dani Welter |
|
| subClassOf |
http://www.ebi.ac.uk/efo/EFO_0004283 |