loading...| Preferred Name | neurofibroma | |
| Synonyms |
[M]Neurofibroma NOS (morphologic abnormality) Neurofibroma NOS (morphologic abnormality) Neurofibroma (morphologic abnormality) Nerve sheath tumor Neurofibroma (disorder) Nerve sheath tumour Neurofibromas Nerve sheath tumor (morphologic abnormality) Neurofibroma, NOS Neurofibroma, no ICD-O subtype Neurofibroma (WHO Grade I) Neurofibroma, no ICD-O subtype (morphologic abnormality) [M]Neurofibromas [M]Neurofibroma NOS |
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| Definitions |
A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands (MeSH). An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors. A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016) |
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| ID |
http://www.ebi.ac.uk/efo/EFO_0000622 |
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| database_cross_reference |
SNOMEDCT:404029005 SNOMEDCT:89084002 NIFSTD:birnlex_12604 MeSH:D009455 MedDRA:10029267 DOID:962 NCIt:C3272 |
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| definition |
A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands (MeSH). An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors. A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016) |
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| has_exact_synonym |
[M]Neurofibroma NOS (morphologic abnormality) Neurofibroma NOS (morphologic abnormality) Neurofibroma (morphologic abnormality) Nerve sheath tumor Neurofibroma (disorder) Nerve sheath tumour Neurofibromas Nerve sheath tumor (morphologic abnormality) Neurofibroma, NOS Neurofibroma, no ICD-O subtype Neurofibroma (WHO Grade I) Neurofibroma, no ICD-O subtype (morphologic abnormality) [M]Neurofibromas [M]Neurofibroma NOS |
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| label |
neurofibroma |
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| preferred label |
neurofibroma |
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| prefixIRI |
efo:EFO_0000622 |
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| prefLabel |
neurofibroma |
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| term editor |
Tomasz Adamusiak James Malone |
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| subClassOf |