loading...| Preferred Name | hepatocellular carcinoma | |
| Synonyms |
adult hepatoma adult primary hepatocellular carcinoma hepatoblastoma caused by somatic mutation liver and intrahepatic bile duct carcinoma liver cancer hepatoblastoma primary carcinoma of the liver cells hepatoblastoma, somatic carcinoma of liver carcinoma of liver cells hepatocellular carcinoma, somatic hepatocellular carcinoma hepatocellular carcinoma, childhood type, somatic carcinoma, hepatocellular, malignant liver carcinoma hepatocellular adenocarcinoma primary carcinoma of liver cells cancer, hepatocellular hepatocellular cancer hepatocellular cancer, somatic carcinoma of the liver cells liver cell carcinoma liver cell cancer (hepatocellular carcinoma) HCC hepatoma |
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| Definitions |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
|
| ID |
http://www.ebi.ac.uk/efo/EFO_0000182 |
|
| closeMatch |
http://purl.obolibrary.org/obo/NCIT_C7711 http://linkedlifedata.com/resource/umls/id/C2676033 http://linkedlifedata.com/resource/umls/id/C0019204 http://identifiers.org/snomedct/25370001 |
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| database_cross_reference |
COHD:4001171 icd11.foundation:1294035808 UMLS:C2239176 OMIM:114550 ICDO:8170/3 MESH:D006528 Orphanet:88673 EFO:0000182 MedDRA:10024658 MEDGEN:389187 MedDRA:10007416 MONDO:0007256 ONCOTREE:HCC MedDRA:10049010 ICD10:C22.0 NANDO:2200047 DOID:684 DOID:686 GARD:16773 NCIT:C3099 NORD:1907 |
|
| definition |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
|
| exactMatch |
http://purl.obolibrary.org/obo/NCIT_C3099 http://identifiers.org/mesh/D006528 http://identifiers.org/omim/114550 http://purl.obolibrary.org/obo/DOID_686 |
|
| gwas_trait |
true |
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| has_exact_synonym |
primary carcinoma of the liver cells hepatoblastoma, somatic carcinoma of liver carcinoma of liver cells hepatocellular carcinoma, somatic hepatocellular carcinoma liver and intrahepatic bile duct carcinoma hepatocellular carcinoma, childhood type, somatic carcinoma, hepatocellular, malignant liver carcinoma hepatocellular adenocarcinoma primary carcinoma of liver cells cancer, hepatocellular hepatocellular cancer hepatocellular cancer, somatic carcinoma of the liver cells liver cell carcinoma liver cell cancer (hepatocellular carcinoma) HCC hepatoma |
|
| has_narrow_synonym |
adult hepatoma adult primary hepatocellular carcinoma |
|
| has_related_synonym |
hepatoblastoma caused by somatic mutation liver and intrahepatic bile duct carcinoma liver cancer hepatoblastoma |
|
| IAO_0000233 | ||
| id |
EFO:0000182 |
|
| in_subset |
http://purl.obolibrary.org/obo/mondo/mondo-base#rare http://purl.obolibrary.org/obo/mondo#ordo_disease http://purl.obolibrary.org/obo/mondo/mondo-base#otar http://purl.obolibrary.org/obo/mondo/mondo-base#gard_rare http://purl.obolibrary.org/obo/mondo/mondo-base#ordo_group_of_disorders |
|
| label |
hepatocellular carcinoma |
|
| notation |
EFO:0000182 |
|
| preferred label |
hepatocellular carcinoma |
|
| prefixIRI |
efo:EFO_0000182 |
|
| prefLabel |
hepatocellular carcinoma |
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| skos_closeMatch | ||
| skos_exactMatch |
http://purl.obolibrary.org/obo/EFO_0000182 http://identifiers.org/medgen/389187 http://purl.obolibrary.org/obo/mondo/sources/icd11foundation/1294035808 http://purl.obolibrary.org/obo/NCIT_C3099 http://identifiers.org/mesh/D006528 http://linkedlifedata.com/resource/umls/id/C2239176 http://purl.obolibrary.org/obo/Orphanet_88673 http://purl.obolibrary.org/obo/DOID_686 |
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| subClassOf |