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BioModels Ontology
Last uploaded:
April 3, 2012
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| Preferred Name | fenfluramine hydrochloride | |
| Synonyms |
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| Definitions |
The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_59729 |
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| alternative term |
InChIKey=ZXKXJHAOUFHNAS-UHFFFAOYSA-N [Cl-].CC[NH2+]C(C)Cc1cccc(c1)C(F)(F)F InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine hydrochloride NN-ethyl-alpha-methyl-3-trifluoromethylphenethylamine hydrochloride (+-)-fenfluramine hydrochloride N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride 1-(3-trifluoromethylphenyl)-2-ethylaminopropane hydrochloride (+-)-fenfluramine HCl C12H17ClF3N N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-aminium chloride fenfluramine HCl
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|
| definition |
The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
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| has part | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_50949 |
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| label |
fenfluramine hydrochloride
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| prefixIRI |
CHEBI:59729
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| prefLabel |
fenfluramine hydrochloride
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| subClassOf |
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