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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Warfarin | |
| Synonyms |
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|
| Definitions |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C945 |
|
| Accepted_Therapeutic_Use_For |
Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment
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|
| ALT_DEFINITION |
A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).
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|
| CAS_Registry |
81-81-2
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|
| CHEBI_ID |
CHEBI:10033
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|
| Chemical_Formula |
C19H16O4
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|
| code |
C945
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.
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|
| Display_Name |
Warfarin
|
|
| FDA_UNII_Code |
5Q7ZVV76EI
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|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Warfarin
|
|
| Legacy Concept Name |
Warfarin
|
|
| NCI_Drug_Dictionary_ID |
39740
|
|
| NSC Number |
59813
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|
| PDQ_Closed_Trial_Search_ID |
39740
|
|
| PDQ_Open_Trial_Search_ID |
39740
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|
| Preferred_Name |
Warfarin
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|
| prefixIRI |
NCIT:C945
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|
| prefLabel |
Warfarin
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0043031
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|
| subClassOf |
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