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Biological and Environmental Research Ontology
| Preferred Name | Verapamil | |
| Synonyms |
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| Definitions |
A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C928 |
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| CAS_Registry |
52-53-9
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| CHEBI_ID |
CHEBI:9948
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| Chemical_Formula |
C27H38N2O4
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|
| code |
C928
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| Contributing_Source |
CTRP FDA
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|
| definition |
A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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| Display_Name |
Verapamil
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| FDA_UNII_Code |
CJ0O37KU29
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Verapamil
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|
| Legacy Concept Name |
Verapamil
|
|
| Maps_To |
Verapamil
|
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| NCI_Drug_Dictionary_ID |
39730
|
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| PDQ_Closed_Trial_Search_ID |
39730
|
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| PDQ_Open_Trial_Search_ID |
39730
|
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| Preferred_Name |
Verapamil
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|
| prefixIRI |
NCIT:C928
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| prefLabel |
Verapamil
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0042523
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| subClassOf |
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