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Biological and Environmental Research Ontology
| Preferred Name | Lacosamide | |
| Synonyms |
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| Definitions |
A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C83859 |
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| CAS_Registry |
175481-36-4
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|
| Chemical_Formula |
C13H18N2O3
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|
| code |
C83859
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.
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| Display_Name |
Lacosamide
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| FDA_UNII_Code |
563KS2PQY5
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Lacosamide
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|
| NCI_Drug_Dictionary_ID |
712043
|
|
| PDQ_Closed_Trial_Search_ID |
712043
|
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| PDQ_Open_Trial_Search_ID |
712043
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| Preferred_Name |
Lacosamide
|
|
| prefixIRI |
NCIT:C83859
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|
| prefLabel |
Lacosamide
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| PubMedID_Primary_Reference |
17395176
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C1311230
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| subClassOf |
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