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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Prothrombin | |
| Synonyms |
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| Definitions |
Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C82854 |
|
| code |
C82854
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| Contributing_Source |
CTRP
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|
| definition |
Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen.
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| DesignNote |
Prothrombin protein can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain, thrombin heavy chain. (UniProt) Prior to secretion, prothrombin is modified to have gamma-carboxyglutamyl residues, resulting from the carboxylation of glutamyl residues by vitamin K-dependent gamma-carboxylase. These modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. (UniProt) Prothrombin catalyzes the cleavage of Arg-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. (UniProt) Prothrombin activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. (UniProt)
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| Display_Name |
Prothrombin
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Prothrombin
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| Legacy Concept Name |
Prothrombin_Gene_Product
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| NCI_META_CUI |
CL449006
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| OMIM_Number |
176930
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| Preferred_Name |
Prothrombin
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| prefixIRI |
NCIT:C82854
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| prefLabel |
Prothrombin
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| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme
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| Swiss_Prot |
P00734
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| subClassOf |
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