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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Porfiromycin | |
| Synonyms |
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| Definitions |
An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C763 |
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| ALT_DEFINITION |
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.
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| CAS_Registry |
801-52-5
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| Chemical_Formula |
C16H20N4O5
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| code |
C763
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| Contributing_Source |
FDA
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| definition |
An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04)
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| FDA_UNII_Code |
H1WK901OA6
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Porfiromycin
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| Legacy Concept Name |
Porfiromycin
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|
| Maps_To |
Porfiromycin
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| NCI_Drug_Dictionary_ID |
39610
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| NSC Number |
56410
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| PDQ_Closed_Trial_Search_ID |
39610
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| PDQ_Open_Trial_Search_ID |
39610
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| Preferred_Name |
Porfiromycin
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| prefixIRI |
NCIT:C763
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| prefLabel |
Porfiromycin
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0032697
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| subClassOf |
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