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Biological and Environmental Research Ontology
| Preferred Name | Rosuvastatin | |
| Synonyms |
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| Definitions |
A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C66523 |
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| CAS_Registry |
287714-41-4
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| CHEBI_ID |
CHEBI:38545
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| Chemical_Formula |
C22H28FN3O6S
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|
| code |
C66523
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| Contributing_Source |
CTRP FDA
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|
| definition |
A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.
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| Display_Name |
Rosuvastatin
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| FDA_UNII_Code |
413KH5ZJ73
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Rosuvastatin
|
|
| Legacy Concept Name |
Rosuvastatin
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|
| Maps_To |
Rosuvastatin
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| NCI_Drug_Dictionary_ID |
654583
|
|
| PDQ_Closed_Trial_Search_ID |
654583
|
|
| PDQ_Open_Trial_Search_ID |
654583
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|
| Preferred_Name |
Rosuvastatin
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|
| prefixIRI |
NCIT:C66523
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|
| prefLabel |
Rosuvastatin
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|
| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0965129
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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