Preferred Name

Isoflurane
Synonyms
Definitions

A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery.

ID

http://purl.obolibrary.org/obo/NCIT_C65978

CAS_Registry

26675-46-7

CHEBI_ID

CHEBI:6015

Chemical_Formula

C3H2ClF5O

code

C65978

Contributing_Source

CPTAC

FDA

definition

A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery.

FDA_UNII_Code

CYS9AKD70P

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C173383

http://purl.obolibrary.org/obo/NCIT_C173381

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C156952

http://purl.obolibrary.org/obo/NCIT_C156953

http://purl.obolibrary.org/obo/NCIT_C159412

label

Isoflurane

Legacy Concept Name

Isoflurane

NCI_Drug_Dictionary_ID

752236

PDQ_Closed_Trial_Search_ID

752236

PDQ_Open_Trial_Search_ID

752236

Preferred_Name

Isoflurane

prefixIRI

NCIT:C65978

prefLabel

Isoflurane

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0022180

subClassOf

http://purl.obolibrary.org/obo/NCIT_C245

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_6015 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387368002 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016613 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6951 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D007530 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/001391 NDDF LOOM
http://stirdf.jst.go.jp/id/200907015777536998 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 OBIB LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 EFO LOOM
http://purl.bioontology.org/ontology/RCD/o25.. RCD LOOM
http://purl.jp/bio/4/id/200906042827771555 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP17885-2 LOINC LOOM
http://purl.obolibrary.org/obo/XCO_0000109 XCO LOOM
http://id.nlm.nih.gov/mesh/D007530 MDM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147364 NDFRT LOOM
https://go.drugbank.com/drugs/DB00753 MDM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000752236 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4019107 VANDF LOOM
http://www.co-ode.org/ontologies/galen#Isoflurane GALEN LOOM
http://psink.de/scio/Isoflurane SCIO LOOM
http://www.pepathway.org/peo/1.2#isoflurane PE-O LOOM
http://purl.bioontology.org/ontology/SNMI/C-6A116 SNMI LOOM
http://purl.obolibrary.org/obo/OMIT_0008645 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/6026 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/N01AB06 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022180 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007530 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/1372-8195 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.355.601.570 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65978 NCIT LOOM
http://www.drugbank.ca/drugs/DB00753 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU024731 LOINC LOOM