Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Bacampicillin
Synonyms
Definitions

A prodrug of ampicillin, a broad-spectrum, semisynthetic, beta-lactam aminopenicillin antibiotic with bactericidal activity. Bacampicillin is hydrolyzed in vivo by esterases to its active metabolite ampicillin. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.
ID

http://purl.obolibrary.org/obo/NCIT_C65245
CAS_Registry

50972-17-3
CHEBI_ID

CHEBI:2968
Chemical_Formula

C21H27N3O7S
code

C65245
Contributing_Source

FDA
definition

A prodrug of ampicillin, a broad-spectrum, semisynthetic, beta-lactam aminopenicillin antibiotic with bactericidal activity. Bacampicillin is hydrolyzed in vivo by esterases to its active metabolite ampicillin. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.
FDA_UNII_Code

8GM2J22278
Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C65246
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Bacampicillin
Legacy Concept Name

Bacampicillin
Preferred_Name

Bacampicillin
prefixIRI

NCIT:C65245
prefLabel

Bacampicillin
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0052865
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1500
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