Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Penicillin Antibiotic
Synonyms
Definitions

Any beta-lactam antibiotic derived from Penicillium fungi with bactericidal activity. Penicillin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
ID

http://purl.obolibrary.org/obo/NCIT_C1500
ALT_DEFINITION

A drug that is used to treat infection. It belongs to the family of drugs called antibiotics.
CHEBI_ID

CHEBI:17334
code

C1500
definition

Any beta-lactam antibiotic derived from Penicillium fungi with bactericidal activity. Penicillin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
label

Penicillin Antibiotic
Legacy Concept Name

Penicillin_Antibiotic
Preferred_Name

Penicillin Antibiotic
prefixIRI

NCIT:C1500
prefLabel

Penicillin Antibiotic
Semantic_Type

Organic Chemical

Antibiotic
UMLS_CUI

C0030842
subClassOf

http://purl.obolibrary.org/obo/NCIT_C260
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