Preferred Name |
Metronidazole |
|
Synonyms |
|
|
Definitions |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C651 |
|
ALT_DEFINITION |
A drug that is used to treat infection and is being studied in the treatment of cancer. It is a type of antibacterial, antiprotozoal, and anthelmintic. |
|
CAS_Registry |
443-48-1 |
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CHEBI_ID |
CHEBI:6909 |
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Chemical_Formula |
C6H9N3O3 |
|
code |
C651 |
|
Contributing_Source |
FDA |
|
definition |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
|
FDA_UNII_Code |
140QMO216E |
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Has_Salt_Form | ||
in_subset | ||
label |
Metronidazole |
|
Legacy Concept Name |
Metronidazole |
|
NSC Number |
50364 69587 |
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Preferred_Name |
Metronidazole |
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prefixIRI |
NCIT:C651 |
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prefLabel |
Metronidazole |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
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UMLS_CUI |
C0025872 |
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subClassOf |