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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Metronidazole | |
| Synonyms |
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| Definitions |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C651 |
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| ALT_DEFINITION |
A drug that is used to treat infection and is being studied in the treatment of cancer. It is a type of antibacterial, antiprotozoal, and anthelmintic.
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| CAS_Registry |
443-48-1
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| CHEBI_ID |
CHEBI:6909
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| Chemical_Formula |
C6H9N3O3
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| code |
C651
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| Contributing_Source |
FDA
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|
| definition |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth.
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| FDA_UNII_Code |
140QMO216E
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Metronidazole
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| Legacy Concept Name |
Metronidazole
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| NSC Number |
50364 69587
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| Preferred_Name |
Metronidazole
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| prefixIRI |
NCIT:C651
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| prefLabel |
Metronidazole
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0025872
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| subClassOf |
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