loading...| Preferred Name | Quinapril | |
| Synonyms |
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| Definitions |
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C62074 |
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| CAS_Registry |
85441-61-8 |
|
| CHEBI_ID |
CHEBI:8713 |
|
| Chemical_Formula |
C25H30N2O5 |
|
| code |
C62074 |
|
| Contributing_Source |
FDA |
|
| definition |
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. |
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| FDA_UNII_Code |
RJ84Y44811 |
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Quinapril |
|
| Legacy Concept Name |
Quinapril_Base |
|
| Preferred_Name |
Quinapril |
|
| prefixIRI |
NCIT:C62074 |
|
| prefLabel |
Quinapril |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0072857 |
|
| subClassOf |