Preferred Name

Pravastatin
Synonyms
Definitions

A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C62070

ALT_DEFINITION

The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.

CAS_Registry

81093-37-0

CHEBI_ID

CHEBI:63618

Chemical_Formula

C23H36O7

code

C62070

Contributing_Source

CTRP

FDA

definition

A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)

Display_Name

Pravastatin

FDA_UNII_Code

KXO2KT9N0G

Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C29375

Has_Target

http://purl.obolibrary.org/obo/NCIT_C54701

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

label

Pravastatin

Legacy Concept Name

Pravastatin_Base

Preferred_Name

Pravastatin

prefixIRI

NCIT:C62070

prefLabel

Pravastatin

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0085542

subClassOf

http://purl.obolibrary.org/obo/NCIT_C1655

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/ATC/C10AA03 ATC LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02126 MIO LOOM
http://purl.obolibrary.org/obo/OMIT_0017454 OMIT LOOM
https://go.drugbank.com/drugs/DB00175 MDM LOOM
http://www.co-ode.org/ontologies/galen#Pravastatin GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017035 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62070 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/42463 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0085542 OCHV LOOM
http://stirdf.jst.go.jp/id/200907020855913870 IOBC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148255 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148255 OCVDAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.930 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/x01R3 RCD LOOM
http://www.semanticweb.org/ontologies/STO.owl#a5dcdea_0bdd_4060_bda4_ef53c4ecb067 STO-DRAFT LOOM
http://www.semanticweb.org/ontologies/STO.owl#a5dcdea_0bdd_4060_bda4_ef53c4ecb067 CVAO LOOM
http://purl.jp/bio/4/id/200906093225057464 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-80820 SNMI LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571353432175145063 ACVD_ONTOLOGY LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373566006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148255 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#15639 OCHV LOOM
http://www.drugbank.ca/drugs/DB00175 FTC LOOM
http://www.owl-ontologies.com/OntologyXCT.owl#Pravastatin CTX LOOM
http://purl.bioontology.org/ontology/VANDF/4020548 VANDF LOOM
http://doe-generated-ontology.com/OntoAD#C0085542 ONTOAD LOOM
http://purl.bioontology.org/ontology/NDDF/003606 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 ODNAE LOOM
http://purl.bioontology.org/ontology/LNC/LP171630-9 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016963 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.930 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D017035 MESH LOOM