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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Nortriptyline | |
| Synonyms |
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| Definitions |
A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C62060 |
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| CAS_Registry |
72-69-5
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| CHEBI_ID |
CHEBI:7640
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| Chemical_Formula |
C19H21N
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| code |
C62060
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| Contributing_Source |
FDA
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|
| definition |
A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.
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| FDA_UNII_Code |
BL03SY4LXB
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Nortriptyline
|
|
| Legacy Concept Name |
Nortriptyline_Base
|
|
| Preferred_Name |
Nortriptyline
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|
| prefixIRI |
NCIT:C62060
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| prefLabel |
Nortriptyline
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0028420
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| subClassOf |
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