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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Enalapril | |
| Synonyms |
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| Definitions |
A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C62027 |
|
| ALT_DEFINITION |
An antihypertensive agent that can also be used to slow or prevent the progression of heart disease in people with childhood cancer treated with drugs that may be harmful to the heart.
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| CAS_Registry |
75847-73-3
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| CHEBI_ID |
CHEBI:4784
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| Chemical_Formula |
C20H28N2O5
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|
| code |
C62027
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| Contributing_Source |
FDA
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|
| definition |
A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
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| FDA_UNII_Code |
69PN84IO1A
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Enalapril
|
|
| Legacy Concept Name |
Enalapril_Base
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|
| Preferred_Name |
Enalapril
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|
| prefixIRI |
NCIT:C62027
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| prefLabel |
Enalapril
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0014025
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| subClassOf |
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