loading...| Preferred Name |
Docetaxel Anhydrous |
|
| Synonyms |
|
|
| Definitions |
The anhydrous form of docetaxel, a semisynthetic side-chain analogue of paclitaxel with antineoplastic property. Docetaxel binds specifically to the beta-tubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. This results in the persistence of aberrant microtubule structures and results in cell-cycle arrest and subsequent cell death. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C61734 |
|
| CAS_Registry |
114977-28-5 |
|
| CHEBI_ID |
CHEBI:4672 |
|
| Chemical_Formula |
C43H53NO14 |
|
| code |
C61734 |
|
| Contributing_Source |
FDA |
|
| definition |
The anhydrous form of docetaxel, a semisynthetic side-chain analogue of paclitaxel with antineoplastic property. Docetaxel binds specifically to the beta-tubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. This results in the persistence of aberrant microtubule structures and results in cell-cycle arrest and subsequent cell death. |
|
| FDA_UNII_Code |
699121PHCA |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Docetaxel Anhydrous |
|
| Legacy Concept Name |
Docetaxel_Anhydrous |
|
| Maps_To |
Docetaxel Anhydrous |
|
| Preferred_Name |
Docetaxel Anhydrous |
|
| prefixIRI |
NCIT:C61734 |
|
| prefLabel |
Docetaxel Anhydrous |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0771375 |
|
| subClassOf |