loading...| Preferred Name | Benazepril | |
| Synonyms |
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| Definitions |
A carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61645 |
|
| CAS_Registry |
86541-75-5 |
|
| CHEBI_ID |
CHEBI:3011 |
|
| Chemical_Formula |
C24H28N2O5 |
|
| code |
C61645 |
|
| Contributing_Source |
FDA |
|
| definition |
A carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| FDA_UNII_Code |
UDM7Q7QWP8 |
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Benazepril |
|
| Legacy Concept Name |
Benazepril |
|
| Preferred_Name |
Benazepril |
|
| prefixIRI |
NCIT:C61645 |
|
| prefLabel |
Benazepril |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0053091 |
|
| subClassOf |