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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Amikacin | |
| Synonyms |
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| Definitions |
A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61615 |
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| ALT_DEFINITION |
An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.
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| CAS_Registry |
37517-28-5
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| CHEBI_ID |
CHEBI:2637
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| Chemical_Formula |
C22H43N5O13
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| code |
C61615
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| Contributing_Source |
FDA
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|
| definition |
A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.
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| FDA_UNII_Code |
84319SGC3C
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Amikacin
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| Legacy Concept Name |
Amikacin_Base
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| Preferred_Name |
Amikacin
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| prefixIRI |
NCIT:C61615
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| prefLabel |
Amikacin
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0002499
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| subClassOf |
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