loading...| Preferred Name | Isotretinoin | |
| Synonyms |
|
|
| Definitions |
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C603 |
|
| Accepted_Therapeutic_Use_For |
Severe recalcitrant nodular acne; psoriasis; cornification disorders; cutaneous T-cell lymphoma; juvenile metastatic neuroblastoma and leukemia |
|
| ALT_DEFINITION |
A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid. |
|
| CAS_Registry |
4759-48-2 |
|
| CHEBI_ID |
CHEBI:6067 |
|
| Chemical_Formula |
C20H28O2 |
|
| code |
C603 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. |
|
| Display_Name |
Isotretinoin |
|
| FDA_UNII_Code |
EH28UP18IF |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Isotretinoin |
|
| Legacy Concept Name |
Isotretinoin |
|
| Maps_To |
Isotretinoin |
|
| NCI_Drug_Dictionary_ID |
42657 |
|
| NSC Number |
329481 |
|
| PDQ_Closed_Trial_Search_ID |
42657 |
|
| PDQ_Open_Trial_Search_ID |
42657 |
|
| Preferred_Name |
Isotretinoin |
|
| prefixIRI |
NCIT:C603 |
|
| prefLabel |
Isotretinoin |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0022265 |
|
| subClassOf |