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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Heparin | |
| Synonyms |
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|
| Definitions |
A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C539 |
|
| Accepted_Therapeutic_Use_For |
Conditions requiring anticoagulation (thrombosis; embolism)
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| ALT_DEFINITION |
A substance that slows the formation of blood clots. Heparin is made by the liver, lungs, and other tissues in the body and can also made in the laboratory. Heparin may be injected into muscle or blood to prevent or break up blood clots. It is a type of anticoagulant.
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| CAS_Registry |
9005-49-6
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| CHEBI_ID |
CHEBI:28304
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| Chemical_Formula |
(C14H18NO11)n.2(C12H16NO13S)n.3HO3S
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|
| code |
C539
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|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots.
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| Display_Name |
Heparin
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| FDA_UNII_Code |
T2410KM04A
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|
| Has_Salt_Form |
http://purl.obolibrary.org/obo/NCIT_C833 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 |
|
| label |
Heparin
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|
| Legacy Concept Name |
Heparin
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|
| NCI_Drug_Dictionary_ID |
40848
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|
| PDQ_Closed_Trial_Search_ID |
40848
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|
| PDQ_Open_Trial_Search_ID |
40848
|
|
| Preferred_Name |
Heparin
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|
| prefixIRI |
NCIT:C539
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|
| prefLabel |
Heparin
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C2825026
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| subClassOf |
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