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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Fluconazole | |
| Synonyms |
|
|
| Definitions |
A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C500 |
|
| Accepted_Therapeutic_Use_For |
Antifungal, prophylaxis in allogeneic bone marrow transplantation; Candidiasis; Cryptococcal meningitis
|
|
| ALT_DEFINITION |
A drug that treats infections caused by fungi.
|
|
| CAS_Registry |
86386-73-4
|
|
| CHEBI_ID |
CHEBI:46081
|
|
| Chemical_Formula |
C13H12F2N6O
|
|
| code |
C500
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.
|
|
| Display_Name |
Fluconazole
|
|
| FDA_UNII_Code |
8VZV102JFY
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Fluconazole
|
|
| Legacy Concept Name |
Fluconazole
|
|
| NCI_Drug_Dictionary_ID |
40842
|
|
| PDQ_Closed_Trial_Search_ID |
40842
|
|
| PDQ_Open_Trial_Search_ID |
40842
|
|
| Preferred_Name |
Fluconazole
|
|
| prefixIRI |
NCIT:C500
|
|
| prefLabel |
Fluconazole
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
|
|
| UMLS_CUI |
C0016277
|
|
| subClassOf |
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