Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Fentanyl | |
| Synonyms |
|
|
| Definitions |
A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C494 |
|
| CAS_Registry |
437-38-7
|
|
| CHEBI_ID |
CHEBI:119915
|
|
| Chemical_Formula |
C22H28N2O
|
|
| code |
C494
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability.
|
|
| Display_Name |
Fentanyl
|
|
| FDA_UNII_Code |
UF599785JZ
|
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Fentanyl
|
|
| Legacy Concept Name |
Fentanyl
|
|
| Preferred_Name |
Fentanyl
|
|
| prefixIRI |
NCIT:C494
|
|
| prefLabel |
Fentanyl
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0591423
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping