loading...| Preferred Name |
Etoposide |
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| Synonyms |
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| Definitions |
A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C491 |
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| Accepted_Therapeutic_Use_For |
Hypereosinophilic syndrome; Kaposi's sarcoma; Langerhans cell histiocytosis; Mobilization of peripheral-blood progenitor cells; Multiple myeloma; Neuroblastoma; Non-small lung cancer; Osteogenic sarcoma Ovarian cancer; Retinoblastoma; Small cell lung cancer; Soft tissue sarcomas; Testicular cancer; Thymoma; Thyroid cancer; Uterine cancer; Wilms' tumor Acute leukemia; Adrenal cortical cancer; Brain cancer; Chronic Lymphocytic leukemia; Choriocarcinoma; Esophageal cancer; Ewing's sarcoma; Gastric cancer; Germ Cell cancer; Gestational trophoblastic neoplasms; Hepatocellular cancer; Hodgkin's disease |
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| ALT_DEFINITION |
A drug used to treat testicular and small cell lung cancers. It is also being studied in the treatment of several other types of cancer. Vepesid blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor. |
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| CAS_Registry |
33419-42-0 |
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| CHEBI_ID |
CHEBI:4911 |
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| Chemical_Formula |
C29H32O13 |
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| code |
C491 |
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| Contributing_Source |
CTRP FDA PCDC |
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| definition |
A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04) |
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| Display_Name |
Etoposide |
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| FDA_UNII_Code |
6PLQ3CP4P3 |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C179531 http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C174019 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C177406 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C179478 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 |
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| Is_PCDC_AML_Permissible_Value_For_Variable | ||
| Is_PCDC_GCT_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Etoposide |
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| Legacy Concept Name |
Etoposide |
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| Maps_To |
Etoposide |
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| NCI_Drug_Dictionary_ID |
39207 |
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| NSC Number |
141540 |
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| PDQ_Closed_Trial_Search_ID |
39207 |
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| PDQ_Open_Trial_Search_ID |
39207 |
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| Preferred_Name |
Etoposide |
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| prefixIRI |
NCIT:C491 |
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| prefLabel |
Etoposide |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0015133 |
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| subClassOf |