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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Telmisartan | |
| Synonyms |
|
|
| Definitions |
A benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47746 |
|
| CAS_Registry |
144701-48-4
|
|
| CHEBI_ID |
CHEBI:9434
|
|
| Chemical_Formula |
C33H30N4O2
|
|
| code |
C47746
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|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure.
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|
| Display_Name |
Telmisartan
|
|
| FDA_UNII_Code |
U5SYW473RQ
|
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 |
|
| label |
Telmisartan
|
|
| Legacy Concept Name |
Telmisartan
|
|
| Preferred_Name |
Telmisartan
|
|
| prefixIRI |
NCIT:C47746
|
|
| prefLabel |
Telmisartan
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|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0248719
|
|
| subClassOf |
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