loading...| Preferred Name |
Perindopril Erbumine |
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| Synonyms |
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| Definitions |
The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47666 |
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| CAS_Registry |
107133-36-8 |
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| CHEBI_ID |
CHEBI:8025 |
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| Chemical_Formula |
C19H32N2O5.C4H11N |
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| code |
C47666 |
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| Contributing_Source |
FDA |
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| definition |
The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. |
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| FDA_UNII_Code |
1964X464OJ |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Perindopril Erbumine |
|
| Legacy Concept Name |
Perindopril_Erbumine |
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| NCI_Drug_Dictionary_ID |
660818 |
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| PDQ_Closed_Trial_Search_ID |
660818 |
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| PDQ_Open_Trial_Search_ID |
660818 |
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| Preferred_Name |
Perindopril Erbumine |
|
| prefixIRI |
NCIT:C47666 |
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| prefLabel |
Perindopril Erbumine |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0244718 |
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| subClassOf |