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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Paromomycin Sulfate | |
| Synonyms |
|
|
| Definitions |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47652 |
|
| CAS_Registry |
1263-89-4
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|
| CHEBI_ID |
CHEBI:7935
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|
| Chemical_Formula |
C23H45N5O14.H2SO4
|
|
| code |
C47652
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|
| Contributing_Source |
FDA
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|
| definition |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death.
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| FDA_UNII_Code |
845NU6GJPS
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|
| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Paromomycin Sulfate
|
|
| Legacy Concept Name |
Paromomycin_Sulfate
|
|
| NCI_Drug_Dictionary_ID |
769609
|
|
| NSC Number |
227228
|
|
| PDQ_Closed_Trial_Search_ID |
769609
|
|
| PDQ_Open_Trial_Search_ID |
769609
|
|
| Preferred_Name |
Paromomycin Sulfate
|
|
| prefixIRI |
NCIT:C47652
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|
| prefLabel |
Paromomycin Sulfate
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0205881
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| subClassOf |
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